Monoubiquitination in Homeostasis and Cancer

Yujie Chen, Dandan Zhou, Yinan Yao, Yutong Sun, Fan Yao, Li Ma

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Monoubiquitination is a post-translational modification (PTM), through which a single ubiquitin molecule is covalently conjugated to a lysine residue of the target protein. Monoubiquitination regulates the activity, subcellular localization, protein–protein interactions, or endocytosis of the substrate. In doing so, monoubiquitination is implicated in diverse cellular processes, including gene transcription, endocytosis, signal transduction, cell death, and DNA damage repair, which in turn regulate cell-cycle progression, survival, proliferation, and stress response. In this review, we summarize the functions of monoubiquitination and discuss how this PTM modulates homeostasis and cancer.

Original languageEnglish (US)
Article number5925
JournalInternational journal of molecular sciences
Volume23
Issue number11
DOIs
StatePublished - Jun 1 2022

Keywords

  • cancer
  • homeostasis
  • monoubiquitination

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

MD Anderson CCSG core facilities

  • Genetically Engineered Mouse Facility
  • Functional Genomics Core

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