Mouse models of metastatic pancreatic adenocarcinoma

Keping Xie; Keping Xie; Bailiang Wang; Qian Shi; James L. Abbruzzese; Qinghua Xiong; Xiangdong Le

doi:10.1385/IJGC:29:1:25

Mouse models of metastatic pancreatic adenocarcinoma

Keping Xie, Keping Xie, Bailiang Wang, Qian Shi, James L. Abbruzzese, Qinghua Xiong, Xiangdong Le

Gastroenterology Hepatology & Nutrition

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Pancreatic adenocarcinoma is a deadly disease. Its etiology is unknown, and metastatic disease kills the majority of patients who have it. Effective prevention is clearly the ultimate goal for eradicating this disease provided that the effects of environmental and genetic elements on pancreatic cancer development are fully understood. Currently, it appears that the control of pancreatic cancer metastasis is of immediate urgency. Fulfillment of this difficult task relies on knowledge of the cellular and molecular biology of metastasis. The use of relevant animal models will help define each aspect of this complicated process.

Original language	English (US)
Pages (from-to)	25-35
Number of pages	11
Journal	International Journal of Pancreatology
Volume	29
Issue number	1
DOIs	https://doi.org/10.1385/IJGC:29:1:25
State	Published - 2001

Keywords

Angiogenesis
Animal model
Metastasis
Nitric oxide
Pancreas

ASJC Scopus subject areas

Oncology
Endocrinology
Gastroenterology

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10.1385/IJGC:29:1:25

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title = "Mouse models of metastatic pancreatic adenocarcinoma",

abstract = "Pancreatic adenocarcinoma is a deadly disease. Its etiology is unknown, and metastatic disease kills the majority of patients who have it. Effective prevention is clearly the ultimate goal for eradicating this disease provided that the effects of environmental and genetic elements on pancreatic cancer development are fully understood. Currently, it appears that the control of pancreatic cancer metastasis is of immediate urgency. Fulfillment of this difficult task relies on knowledge of the cellular and molecular biology of metastasis. The use of relevant animal models will help define each aspect of this complicated process.",

keywords = "Angiogenesis, Animal model, Metastasis, Nitric oxide, Pancreas",

author = "Keping Xie and Keping Xie and Bailiang Wang and Qian Shi and Abbruzzese, {James L.} and Qinghua Xiong and Xiangdong Le",

note = "Funding Information: We thank Don Norwood for editorial comments, and Judy King for assistance in the preparation of this manuscript. The research work in our laboratory is supported by the Marc Lustgartet Pancreatic Cancer Foundation, Research Project Grant #RPG-00-054-01-CMS from the American Cancer Society, the Physician Referral Service Award, and Cancer Center Support Core Grant CA 6672-23 from the National Institutes of Health (to K.X.).",

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T1 - Mouse models of metastatic pancreatic adenocarcinoma

AU - Xie, Keping

AU - Wang, Bailiang

AU - Shi, Qian

AU - Abbruzzese, James L.

AU - Xiong, Qinghua

AU - Le, Xiangdong

N1 - Funding Information: We thank Don Norwood for editorial comments, and Judy King for assistance in the preparation of this manuscript. The research work in our laboratory is supported by the Marc Lustgartet Pancreatic Cancer Foundation, Research Project Grant #RPG-00-054-01-CMS from the American Cancer Society, the Physician Referral Service Award, and Cancer Center Support Core Grant CA 6672-23 from the National Institutes of Health (to K.X.).

PY - 2001

Y1 - 2001

N2 - Pancreatic adenocarcinoma is a deadly disease. Its etiology is unknown, and metastatic disease kills the majority of patients who have it. Effective prevention is clearly the ultimate goal for eradicating this disease provided that the effects of environmental and genetic elements on pancreatic cancer development are fully understood. Currently, it appears that the control of pancreatic cancer metastasis is of immediate urgency. Fulfillment of this difficult task relies on knowledge of the cellular and molecular biology of metastasis. The use of relevant animal models will help define each aspect of this complicated process.

AB - Pancreatic adenocarcinoma is a deadly disease. Its etiology is unknown, and metastatic disease kills the majority of patients who have it. Effective prevention is clearly the ultimate goal for eradicating this disease provided that the effects of environmental and genetic elements on pancreatic cancer development are fully understood. Currently, it appears that the control of pancreatic cancer metastasis is of immediate urgency. Fulfillment of this difficult task relies on knowledge of the cellular and molecular biology of metastasis. The use of relevant animal models will help define each aspect of this complicated process.

KW - Angiogenesis

KW - Animal model

KW - Metastasis

KW - Nitric oxide

KW - Pancreas

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Mouse models of metastatic pancreatic adenocarcinoma

Abstract

Keywords

ASJC Scopus subject areas

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