TY - JOUR
T1 - Mucoepidermoid carcinoma ex pleomorphic adenoma
T2 - Nonspecific preoperative cytologic findings in six cases
AU - Klijanienko, Jerzy
AU - El-Naggar, Adel K.
AU - Servois, Vincent
AU - Rodriguez, Joseph
AU - Validire, Pierre
AU - Vielh, Philippe
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998/8/25
Y1 - 1998/8/25
N2 - BACKGROUND. In contrast to most major salivary gland malignancies, mucoepidermoid carcinoma has been rarely documented and tentatively accepted as carcinoma ex pleomorphic adenoma. The authors present the cytologic and clinical findings for six examples of these rare tumors. METHODS. The six examples were identified during an extensive review of the authors' salivary gland files, and all were high grade mucoepidermoid carcinomas on histologic evaluation. RESULTS. Overall, mucoepidermoid carcinomas cytologically presented as nonspecific high grade malignancies and consisted of highly malignant cells, in clusters or isolated, that were rarely associated with intracellular and extracellular mucin. In only two cases, a background of cellular and stromal elements consistent with pleomorphic adenoma was identified. CONCLUSIONS. Although it is nearly impossible cytologically to distinguish these lesions from other high grade primary or metastatic carcinomas (such as poorly differentiated squamous cell carcinomas, adenosquamous carcinomas, and salivary duct carcinomas), this limitation is not dramatic, as a cytologic diagnosis of high grade malignancy per se allows for proper preoperative patient management.
AB - BACKGROUND. In contrast to most major salivary gland malignancies, mucoepidermoid carcinoma has been rarely documented and tentatively accepted as carcinoma ex pleomorphic adenoma. The authors present the cytologic and clinical findings for six examples of these rare tumors. METHODS. The six examples were identified during an extensive review of the authors' salivary gland files, and all were high grade mucoepidermoid carcinomas on histologic evaluation. RESULTS. Overall, mucoepidermoid carcinomas cytologically presented as nonspecific high grade malignancies and consisted of highly malignant cells, in clusters or isolated, that were rarely associated with intracellular and extracellular mucin. In only two cases, a background of cellular and stromal elements consistent with pleomorphic adenoma was identified. CONCLUSIONS. Although it is nearly impossible cytologically to distinguish these lesions from other high grade primary or metastatic carcinomas (such as poorly differentiated squamous cell carcinomas, adenosquamous carcinomas, and salivary duct carcinomas), this limitation is not dramatic, as a cytologic diagnosis of high grade malignancy per se allows for proper preoperative patient management.
KW - Carcinoma ex pleomorphic adenoma
KW - Cytology
KW - Malignant mixed tumor
KW - Mucoepidermoid carcinoma ex mixed tumor
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U2 - 10.1002/(SICI)1097-0142(19980825)84:4<231::AID-CNCR8>3.0.CO;2-P
DO - 10.1002/(SICI)1097-0142(19980825)84:4<231::AID-CNCR8>3.0.CO;2-P
M3 - Article
C2 - 9723598
AN - SCOPUS:0032566418
SN - 0008-543X
VL - 84
SP - 231
EP - 234
JO - Cancer
JF - Cancer
IS - 4
ER -