Mucus hypersecretion in asthma: Causes and effects

Christopher M. Evans; Kyubo Kim; Michael J. Tuvim; Burton F. Dickey

doi:10.1097/MCP.0b013e32831da8d3

Mucus hypersecretion in asthma: Causes and effects

Christopher M. Evans, Kyubo Kim, Michael J. Tuvim, Burton F. Dickey

Pulmonary Medicine

Research output: Contribution to journal › Review article › peer-review

224 Scopus citations

Abstract

Markedly upregulated production of MUC5AC together with stimulated secretion leads to airflow obstruction in asthma. As MUC5B appears to mediate homeostatic functions, it may be possible to selectively inhibit MUC5AC production without impairing airway function. The precise roles of mucin hypersecretion in asthma symptoms such as dyspnea and cough and in physiologic phenomena such as airway hyperresponsiveness remain to be defined.

Original language	English (US)
Pages (from-to)	4-11
Number of pages	8
Journal	Current opinion in pulmonary medicine
Volume	15
Issue number	1
DOIs	https://doi.org/10.1097/MCP.0b013e32831da8d3
State	Published - Jan 2009

Keywords

Airway
Asthma
Mucin
Mucous
Mucus

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

MD Anderson CCSG core facilities

Genetically Engineered Mouse Facility

Access to Document

10.1097/MCP.0b013e32831da8d3

Cite this

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AU - Tuvim, Michael J.

AU - Dickey, Burton F.

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AB - Markedly upregulated production of MUC5AC together with stimulated secretion leads to airflow obstruction in asthma. As MUC5B appears to mediate homeostatic functions, it may be possible to selectively inhibit MUC5AC production without impairing airway function. The precise roles of mucin hypersecretion in asthma symptoms such as dyspnea and cough and in physiologic phenomena such as airway hyperresponsiveness remain to be defined.

KW - Airway

KW - Asthma

KW - Mucin

KW - Mucous

KW - Mucus

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Mucus hypersecretion in asthma: Causes and effects

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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