TY - JOUR
T1 - Multi-center feasibility study evaluating recruitment, variability in risk factors and biomarkers for a diet and cancer cohort in India
AU - Sinha, Rashmi
AU - Daniel, Carrie R.
AU - Devasenapathy, Niveditha
AU - Shetty, Hemali
AU - Yurgalevitch, Susan
AU - Ferrucci, Leah M.
AU - George, Preethi S.
AU - Morrissey, Kerry Grace
AU - Ramakrishnan, Lakshmy
AU - Graubard, Barry I.
AU - Kapur, Kavita
AU - Reddy, K. Srinath
AU - McAdams, Mary J.
AU - Rastogi, Tanuja
AU - Chatterjee, Nilanjan
AU - Gupta, Prakash C.
AU - Wacholder, Sholom
AU - Prabhakaran, Dorairaj
AU - Mathew, Aleyamma A.
N1 - Funding Information:
We are indebted to the participants in the IHS for their patience and outstanding cooperation even during the busy times of their day. This research was supported by the Intramural Research Program of the NIH, National Cancer Institute. The authors would like to thank all the field, laboratory, data-entry, and office staff at the three centers for their dedicated work to make this study possible. Our special thanks go to Sriram Hariharan of Atribs for developing the NINA-DISH software and Puneet Chadda for taking charge of the New Delhi dietary component, and Mangesh Pednekar and Binukumar for their continued support. The network support provided by the team at the Capital Technology Information Services, Inc., Raj Shah, Anil Srivastava, Chirag Shah, Sachin Parikh, and Keyur Shah, was invaluable for the success of the IHS. We would also like to expresses our gratitude to Eric Berger of the Information Management Systems, Inc., and Judy Walsh, Sujata Dixit-Joshi and Viji Narayana of Westat for data management.
PY - 2011
Y1 - 2011
N2 - Background: India's population exhibits diverse dietary habits and chronic disease patterns. Nutritional epidemiologic studies in India are primarily of cross-sectional or case-control design and subject to biases, including differential recall of past diet. The aim of this feasibility study was to evaluate whether a diet-focused cohort study of cancer could be established in India, providing insight into potentially unique diet and lifestyle exposures. Methods. Field staff contacted 7,064 households within three regions of India (New Delhi, Mumbai, and Trivandrum) and found 4,671 eligible adults aged 35-69 years. Participants completed interviewer-administered questionnaires (demographic, diet history, physical activity, medical/reproductive history, tobacco/alcohol use, and occupational history), and staff collected biological samples (blood, urine, and toenail clippings), anthropometric measurements (weight, standing and sitting height; waist, hip, and thigh circumference; triceps, sub-scapula and supra-patella skin fold), and blood pressure measurements. Results: Eighty-eight percent of eligible subjects completed all questionnaires and 67% provided biological samples. Unique protein sources by region were fish in Trivandrum, dairy in New Delhi, and pulses (legumes) in Mumbai. Consumption of meat, alcohol, fast food, and soft drinks was scarce in all three regions. A large percentage of the participants were centrally obese and had elevated blood glucose levels. New Delhi participants were also the least physically active and had elevated lipids levels, suggesting a high prevalence of metabolic syndrome. Conclusions: A high percentage of participants complied with study procedures including biological sample collection. Epidemiologic expertise and sufficient infrastructure exists at these three sites in India to successfully carry out a modest sized population-based study; however, we identified some potential problems in conducting a cohort study, such as limited number of facilities to handle biological samples.
AB - Background: India's population exhibits diverse dietary habits and chronic disease patterns. Nutritional epidemiologic studies in India are primarily of cross-sectional or case-control design and subject to biases, including differential recall of past diet. The aim of this feasibility study was to evaluate whether a diet-focused cohort study of cancer could be established in India, providing insight into potentially unique diet and lifestyle exposures. Methods. Field staff contacted 7,064 households within three regions of India (New Delhi, Mumbai, and Trivandrum) and found 4,671 eligible adults aged 35-69 years. Participants completed interviewer-administered questionnaires (demographic, diet history, physical activity, medical/reproductive history, tobacco/alcohol use, and occupational history), and staff collected biological samples (blood, urine, and toenail clippings), anthropometric measurements (weight, standing and sitting height; waist, hip, and thigh circumference; triceps, sub-scapula and supra-patella skin fold), and blood pressure measurements. Results: Eighty-eight percent of eligible subjects completed all questionnaires and 67% provided biological samples. Unique protein sources by region were fish in Trivandrum, dairy in New Delhi, and pulses (legumes) in Mumbai. Consumption of meat, alcohol, fast food, and soft drinks was scarce in all three regions. A large percentage of the participants were centrally obese and had elevated blood glucose levels. New Delhi participants were also the least physically active and had elevated lipids levels, suggesting a high prevalence of metabolic syndrome. Conclusions: A high percentage of participants complied with study procedures including biological sample collection. Epidemiologic expertise and sufficient infrastructure exists at these three sites in India to successfully carry out a modest sized population-based study; however, we identified some potential problems in conducting a cohort study, such as limited number of facilities to handle biological samples.
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U2 - 10.1186/1471-2458-11-405
DO - 10.1186/1471-2458-11-405
M3 - Article
C2 - 21619649
AN - SCOPUS:79957506296
SN - 1471-2458
VL - 11
JO - BMC public health
JF - BMC public health
M1 - 405
ER -