@article{f3364938a0294c6cad771d6ed819b434,
title = "Multi-institutional retrospective review of stereotactic radiosurgery for brain metastasis in patients with small-cell lung cancer without prior brain-directed radiotherapy",
abstract = "Introduction: Patients with small cell lung cancer (SCLC) brain metastasis (BM) typically receive whole brain radiotherapy (WBRT) as data regarding upfront radiosurgery (SRS) in this setting are sparse. Methods: Patients receiving SRS for SCLC BM without prior brain radiation were identified at three U.S. institutions. Overall survival (OS), freedom from intracranial progression (FFIP), freedom from WBRT (FFWBRT), and freedom from neurologic death (FFND) were determined from time of SRS. Results: Thirty-three patients were included with a median of 2 BM (IQR 1-6). Median OS and FFIP were 6.7 and 5.8 months, respectively. Median FFIP for patients with ≤2 versus >2 BM was 7.1 versus 3.6 months, p=0.0303. Eight patients received salvage WBRT and the 6-month FFWBRT and FFND were 87.8%. and 90.1%, respectively. Conclusions: Most SCLC patients with BM who received upfront SRS avoided WBRT and neurologic death, suggesting that SRS may be an option in select patients.",
keywords = "Brain metastasis, Small cell lung cancer, Stereotactic radiosurgery, Survival",
author = "Miccio, {Joseph A.} and Andrew Barsky and Sarah Gao and Vivek Verma and Noticewala, {Sonal S.} and Vikram Jairam and Johnson, {Skyler B.} and Yu, {James B.} and Hansen, {James E.} and Sanjay Aneja and Yi An and Decker, {Roy H.} and Omay, {S. Bulent} and Jing Li and Kurtz, {Goldie A.} and Michelle Alonso-Basanta and Lee, {John Y.K.} and Chiang, {Veronica L.} and Park, {Henry S.}",
note = "Funding Information: Dr. Alonso-Basanta reports support from Varian and IBA outside of the submitted work. Dr. Aneja reports grants from AHRQ, grants from NSF, and grants from the American Cancer Society outside of the submitted work. Dr. Hansen reports grants and from Patrys and multiple patents related to use of autoantibodies against cancer outside of the submitted work. Dr. Park reports honoraria from Rad Onc Questions LLC outside of the submitted work. Dr. Yu reports personal fees from Boston Scientific and personal fees from Galera Pharmaceuticals outside of the submitted work. Drs. An, Barsky, Chiang, Decker, Gao, Jairam, Johnson, Kurtz, Lee, Li, Miccio, Noticewala, Omay and Verma declare that they have no conflict of interest. Publisher Copyright: {\textcopyright} 2020 Old City Publishing, Inc.",
year = "2020",
language = "English (US)",
volume = "7",
pages = "19--27",
journal = "Journal of Radiosurgery and SBRT",
issn = "2156-4639",
publisher = "Old City Publishing",
number = "1",
}