Multi-layered polymeric nanoparticles for pH-responsive and sequenced release of theranostic agents

Hai Wang; Shuting Zhao; Pranay Agarwal; Jenna Dumbleton; Jianhua Yu; Xiongbin Lu; Xiaoming He

doi:10.1039/c5cc01833a

Multi-layered polymeric nanoparticles for pH-responsive and sequenced release of theranostic agents

Hai Wang, Shuting Zhao, Pranay Agarwal, Jenna Dumbleton, Jianhua Yu, Xiongbin Lu, Xiaoming He

Cancer Biology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

In this study, multi-layered pH-responsive polymeric nanoparticles (NPs) are prepared by multiple (up to 4) emulsifications to encapsulate multiple hydrophilic and hydrophobic theranostic agents for controlled and sequenced release. It is found that the sequence of release of multiple chemotherapeutic agents from the NPs significantly affects their efficacy against cancer cells.

Original language	English (US)
Pages (from-to)	7733-7736
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	36
DOIs	https://doi.org/10.1039/c5cc01833a
State	Published - May 4 2015

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "In this study, multi-layered pH-responsive polymeric nanoparticles (NPs) are prepared by multiple (up to 4) emulsifications to encapsulate multiple hydrophilic and hydrophobic theranostic agents for controlled and sequenced release. It is found that the sequence of release of multiple chemotherapeutic agents from the NPs significantly affects their efficacy against cancer cells.",

author = "Hai Wang and Shuting Zhao and Pranay Agarwal and Jenna Dumbleton and Jianhua Yu and Xiongbin Lu and Xiaoming He",

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AU - Wang, Hai

AU - Zhao, Shuting

AU - Agarwal, Pranay

AU - Dumbleton, Jenna

AU - Yu, Jianhua

AU - Lu, Xiongbin

AU - He, Xiaoming

PY - 2015/5/4

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AB - In this study, multi-layered pH-responsive polymeric nanoparticles (NPs) are prepared by multiple (up to 4) emulsifications to encapsulate multiple hydrophilic and hydrophobic theranostic agents for controlled and sequenced release. It is found that the sequence of release of multiple chemotherapeutic agents from the NPs significantly affects their efficacy against cancer cells.

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Multi-layered polymeric nanoparticles for pH-responsive and sequenced release of theranostic agents

Abstract

ASJC Scopus subject areas

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