TY - JOUR
T1 - Multifocal and multicentric glioblastoma
T2 - Imaging signature, molecular characterization, patterns of spread, and treatment
AU - Farhat, Maguy
AU - Fuller, Gregory N.
AU - Wintermark, Max
AU - Chung, Caroline
AU - Kumar, Vinodh A.
AU - Chen, Melissa
N1 - Publisher Copyright:
© The Author(s) 2023.
PY - 2023
Y1 - 2023
N2 - Multifocal and multicentric glioblastoma (GBM) or collectively, m-GBM, is an imaging diagnosis present in up to 34% of patients with GBM. Compared to unifocal disease, patients with m-GBM have worse outcomes owing to the enhanced aggressive nature of the disease and its resistance to currently available treatments. To improve the understanding of its complex behavior, many associations have been established between the radiologic findings of m-GBM and its gross histology, genetic composition, and patterns of spread. Additionally, the holistic knowledge of the exact mechanisms of m-GBM genesis and progression is crucial for identifying potential targets permitting enhanced diagnosis and treatment. In this review, we aim to provide a comprehensive summary of the cumulative knowledge of the unique molecular biology and behavior of m-GBM and the association of these features with neuroimaging.
AB - Multifocal and multicentric glioblastoma (GBM) or collectively, m-GBM, is an imaging diagnosis present in up to 34% of patients with GBM. Compared to unifocal disease, patients with m-GBM have worse outcomes owing to the enhanced aggressive nature of the disease and its resistance to currently available treatments. To improve the understanding of its complex behavior, many associations have been established between the radiologic findings of m-GBM and its gross histology, genetic composition, and patterns of spread. Additionally, the holistic knowledge of the exact mechanisms of m-GBM genesis and progression is crucial for identifying potential targets permitting enhanced diagnosis and treatment. In this review, we aim to provide a comprehensive summary of the cumulative knowledge of the unique molecular biology and behavior of m-GBM and the association of these features with neuroimaging.
KW - glioblastoma
KW - magnetic resonance imaging
KW - molecular markers
KW - multicentric glioblastoma
KW - multifocal glioblastoma
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U2 - 10.1177/19714009231193162
DO - 10.1177/19714009231193162
M3 - Review article
C2 - 37559514
AN - SCOPUS:85167427958
SN - 1971-4009
JO - Neuroradiology Journal
JF - Neuroradiology Journal
ER -