Multifunctional Cu 2'x Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453

Aby Cheruvathoor Poulose; Srivani Veeranarayanan; M. Sheikh Mohamed; Rebeca Romero Aburto; Trevor Mitcham; Richard R. Bouchard; Pulickel M. Ajayan; Yasushi Sakamoto; Toru Maekawa; D. Sakthi Kumar

doi:10.1038/srep35961

Multifunctional Cu 2'x Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453

Aby Cheruvathoor Poulose, Srivani Veeranarayanan, M. Sheikh Mohamed, Rebeca Romero Aburto, Trevor Mitcham, Richard R. Bouchard, Pulickel M. Ajayan, Yasushi Sakamoto, Toru Maekawa, D. Sakthi Kumar

Imaging Physics

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu 2'X Te) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies.

Original language	English (US)
Article number	35961
Journal	Scientific reports
Volume	6
DOIs	https://doi.org/10.1038/srep35961
State	Published - Oct 24 2016

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title = "Multifunctional Cu 2'x Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453",

abstract = "Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu 2'X Te) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies.",

author = "Poulose, {Aby Cheruvathoor} and Srivani Veeranarayanan and Mohamed, {M. Sheikh} and Aburto, {Rebeca Romero} and Trevor Mitcham and Bouchard, {Richard R.} and Ajayan, {Pulickel M.} and Yasushi Sakamoto and Toru Maekawa and Kumar, {D. Sakthi}",

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doi = "10.1038/srep35961",

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AU - Poulose, Aby Cheruvathoor

AU - Veeranarayanan, Srivani

AU - Mohamed, M. Sheikh

AU - Aburto, Rebeca Romero

AU - Mitcham, Trevor

AU - Bouchard, Richard R.

AU - Ajayan, Pulickel M.

AU - Sakamoto, Yasushi

AU - Maekawa, Toru

AU - Kumar, D. Sakthi

PY - 2016/10/24

Y1 - 2016/10/24

N2 - Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu 2'X Te) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies.

AB - Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu 2'X Te) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies.

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Multifunctional Cu 2'x Te Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453

Abstract

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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