Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer

Mustafa Akkiprik; Yumei Feng; Huamin Wang; Kexin Chen; Limei Hu; Aysegul Sahin; Savitri Krishnamurthy; Ayse Ozer; Xishan Hao; Wei Zhang

doi:10.1186/bcr2116

Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer

Mustafa Akkiprik, Yumei Feng, Huamin Wang, Kexin Chen, Limei Hu, Aysegul Sahin, Savitri Krishnamurthy, Ayse Ozer, Xishan Hao, Wei Zhang

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.

Original language	English (US)
Article number	212
Journal	Breast Cancer Research
Volume	10
Issue number	4
DOIs	https://doi.org/10.1186/bcr2116
State	Published - Aug 11 2008

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1186/bcr2116

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title = "Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer",

abstract = "The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.",

author = "Mustafa Akkiprik and Yumei Feng and Huamin Wang and Kexin Chen and Limei Hu and Aysegul Sahin and Savitri Krishnamurthy and Ayse Ozer and Xishan Hao and Wei Zhang",

note = "Funding Information: The authors would like to thank Michael Worley in the Department of Scientific Publication at the MD Anderson Cancer Center for editing the manuscript. This work is partly supported by a grant (BC044966 to WZ) from the Department of Defense Breast Cancer Research Program of the Office of the Congressionally Directed Medical Research Programs.",

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doi = "10.1186/bcr2116",

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T1 - Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer

AU - Akkiprik, Mustafa

AU - Feng, Yumei

AU - Wang, Huamin

AU - Chen, Kexin

AU - Hu, Limei

AU - Sahin, Aysegul

AU - Krishnamurthy, Savitri

AU - Ozer, Ayse

AU - Hao, Xishan

AU - Zhang, Wei

N1 - Funding Information: The authors would like to thank Michael Worley in the Department of Scientific Publication at the MD Anderson Cancer Center for editing the manuscript. This work is partly supported by a grant (BC044966 to WZ) from the Department of Defense Breast Cancer Research Program of the Office of the Congressionally Directed Medical Research Programs.

PY - 2008/8/11

Y1 - 2008/8/11

N2 - The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.

AB - The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.

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DO - 10.1186/bcr2116

M3 - Review article

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JO - Breast Cancer Research

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ER -

Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer

Abstract

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