Multilayer-Analyse der Signaltransduktion und Zellzykluskontrolle in GIST Identifizierung neuer Interaktionspartner mit differenzieller Regulation

F. Haller; D. J. Zhang; C. Löbke; A. Von Heydebreck; U. Korf; L. Füzesi; Ö Sahin

doi:10.1007/s00292-010-1339-5

Multilayer-Analyse der Signaltransduktion und Zellzykluskontrolle in GIST Identifizierung neuer Interaktionspartner mit differenzieller Regulation

Translated title of the contribution: Multilayer analysis of signal transduction and cell cycle control in GIST. Indentifying new interaction partners with differential regulation

F. Haller, D. J. Zhang, C. Löbke, A. Von Heydebreck, U. Korf, L. Füzesi, Ö Sahin

Molecular & Cellular Oncology

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

To identify new interactions as well as diagnostically, prognostically and therapeutically relevant differences in the regulation of gene expression in gastrointestinal stromal tumors (GISTs), we analyzed the methylation status, mRNA expression, microRNA expression, protein expression and protein phosphorylation in parallel in identical tumor tissue samples. The data were analyzed in a multilayer approach and were correlated to each other and to clinico-pathological parameters. Differentially regulated genes were mapped to signal transduction pathways which are already known to play a major role in GISTs. A functionally orientated overview of the different data layers was constructed, which enabled new insights into gene regulation in GISTs.

Translated title of the contribution	Multilayer analysis of signal transduction and cell cycle control in GIST. Indentifying new interaction partners with differential regulation
Original language	German
Pages (from-to)	134-137
Number of pages	4
Journal	Pathologe
Volume	31
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1007/s00292-010-1339-5
State	Published - Oct 2010

Keywords

Gastrointestinal stromal tumors
Methylation
MicroRNA
Protein
RNA, messenger

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1007/s00292-010-1339-5

Cite this

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title = "Multilayer-Analyse der Signaltransduktion und Zellzykluskontrolle in GIST Identifizierung neuer Interaktionspartner mit differenzieller Regulation",

abstract = "To identify new interactions as well as diagnostically, prognostically and therapeutically relevant differences in the regulation of gene expression in gastrointestinal stromal tumors (GISTs), we analyzed the methylation status, mRNA expression, microRNA expression, protein expression and protein phosphorylation in parallel in identical tumor tissue samples. The data were analyzed in a multilayer approach and were correlated to each other and to clinico-pathological parameters. Differentially regulated genes were mapped to signal transduction pathways which are already known to play a major role in GISTs. A functionally orientated overview of the different data layers was constructed, which enabled new insights into gene regulation in GISTs.",

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AU - Zhang, D. J.

AU - Löbke, C.

AU - Von Heydebreck, A.

AU - Korf, U.

AU - Füzesi, L.

AU - Sahin, Ö

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AB - To identify new interactions as well as diagnostically, prognostically and therapeutically relevant differences in the regulation of gene expression in gastrointestinal stromal tumors (GISTs), we analyzed the methylation status, mRNA expression, microRNA expression, protein expression and protein phosphorylation in parallel in identical tumor tissue samples. The data were analyzed in a multilayer approach and were correlated to each other and to clinico-pathological parameters. Differentially regulated genes were mapped to signal transduction pathways which are already known to play a major role in GISTs. A functionally orientated overview of the different data layers was constructed, which enabled new insights into gene regulation in GISTs.

KW - Gastrointestinal stromal tumors

KW - Methylation

KW - MicroRNA

KW - Protein

KW - RNA, messenger

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Multilayer-Analyse der Signaltransduktion und Zellzykluskontrolle in GIST Identifizierung neuer Interaktionspartner mit differenzieller Regulation

Abstract

Keywords

ASJC Scopus subject areas

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