TY - JOUR
T1 - Multimodal snapshot spectral imaging for oral cancer diagnostics
T2 - A pilot study
AU - Bedard, Noah
AU - Schwarz, Richard A.
AU - Hu, Aaron
AU - Bhattar, Vijayashree
AU - Howe, Jana
AU - Williams, Michelle D.
AU - Gillenwater, Ann M.
AU - Richards-Kortum, Rebecca
AU - Tkaczyk, Tomasz S.
PY - 2013
Y1 - 2013
N2 - Optical imaging and spectroscopy have emerged as effective tools for detecting malignant changes associated with oral cancer. While clinical studies have demonstrated high sensitivity and specificity for detection, current devices either interrogate a small region or can have reduced performance for some benign lesions. We describe a snapshot imaging spectrometer that combines the large field-of-view of widefield imaging with the diagnostic strength of spectroscopy. The portable device can stream RGB images at 7.2 frames per second and record both autofluorescence and reflectance spectral datacubes in < 1 second. We report initial data from normal volunteers and oral cancer patients.
AB - Optical imaging and spectroscopy have emerged as effective tools for detecting malignant changes associated with oral cancer. While clinical studies have demonstrated high sensitivity and specificity for detection, current devices either interrogate a small region or can have reduced performance for some benign lesions. We describe a snapshot imaging spectrometer that combines the large field-of-view of widefield imaging with the diagnostic strength of spectroscopy. The portable device can stream RGB images at 7.2 frames per second and record both autofluorescence and reflectance spectral datacubes in < 1 second. We report initial data from normal volunteers and oral cancer patients.
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U2 - 10.1364/BOE.4.000938
DO - 10.1364/BOE.4.000938
M3 - Article
C2 - 23760882
AN - SCOPUS:84878493241
SN - 2156-7085
VL - 4
SP - 938
EP - 949
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 6
ER -