TY - JOUR
T1 - Multiple faces of the SAGA complex
AU - Koutelou, Evangelia
AU - Hirsch, Calley L.
AU - Dent, Sharon Y.R.
N1 - Funding Information:
We thank Boyko Atanassov, Yi Chun Chen, Andria Schibler, and Marenda Wilson-Pham for useful comments and discussions on the manuscript. Calley L Hirsch is funded as an Odyssey Fellow supported by the Odyssey Program and the Houston Endowment Inc., Award for Scientific Achievement at The University of Texas M.D. Anderson Cancer Center. Parts of this work were supported by a grant from the NIH to SYRD, GM067718.
PY - 2010/6
Y1 - 2010/6
N2 - The SAGA complex provides a paradigm for multisubunit histone modifying complexes. Although first characterized as a histone acetyltransferase, because of the Gcn5 subunit, SAGA is now known to contain a second activity, a histone deubiquitinase, as well as subunits important for interactions with transcriptional activators and the general transcription machinery. The functions of SAGA in transcriptional activation are well-established in Saccharomyces cerevisiae. Recent studies in S. pombe, Drosophila, and mammalian systems reveal that SAGA also has important roles in transcript elongation, the regulation of protein stability, and telomere maintenance. These functions are essential for normal embryo development in flies and mice, and mutations or altered expression of SAGA subunits correlate with neurological disease and aggressive cancers in humans.
AB - The SAGA complex provides a paradigm for multisubunit histone modifying complexes. Although first characterized as a histone acetyltransferase, because of the Gcn5 subunit, SAGA is now known to contain a second activity, a histone deubiquitinase, as well as subunits important for interactions with transcriptional activators and the general transcription machinery. The functions of SAGA in transcriptional activation are well-established in Saccharomyces cerevisiae. Recent studies in S. pombe, Drosophila, and mammalian systems reveal that SAGA also has important roles in transcript elongation, the regulation of protein stability, and telomere maintenance. These functions are essential for normal embryo development in flies and mice, and mutations or altered expression of SAGA subunits correlate with neurological disease and aggressive cancers in humans.
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U2 - 10.1016/j.ceb.2010.03.005
DO - 10.1016/j.ceb.2010.03.005
M3 - Review article
C2 - 20363118
AN - SCOPUS:77954816833
SN - 0955-0674
VL - 22
SP - 374
EP - 382
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -