Multiple relapses in high-grade osteosarcoma: When to stop aggressive therapy?

Gevorg Tamamyan; Martin Dominkus; Susanna Lang; Christopher Diakos; Edda Mittheisz; Ernst Horcher; Wolfgang Holter; Andreas Zoubek; Stefan Bielack; Leo Kager

doi:10.1002/pbc.25360

Multiple relapses in high-grade osteosarcoma: When to stop aggressive therapy?

Gevorg Tamamyan, Martin Dominkus, Susanna Lang, Christopher Diakos, Edda Mittheisz, Ernst Horcher, Wolfgang Holter, Andreas Zoubek, Stefan Bielack, Leo Kager

Leukemia

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7 Scopus citations

Abstract

The prognosis after relapse of high-grade osteosarcoma is poor and complete resection of all tumors is essential for survival. A 6-year old was diagnosed with high-grade osteosarcoma and treated according to the COSS-96 protocol. Within 5 years from initial diagnosis, five osteosarcoma relapses occurred and every time it was possible to achieve complete surgical remission. Additional treatments included chemotherapy and dendritic cell-based cancer immune therapy. Since the end of therapy of the 5th relapse, he is alive for 111/2 years. Our experience further supports that aggressive surgery can help to achieve long-term survival even in patients with multiple osteosarcoma relapses.

Original language	English (US)
Pages (from-to)	529-530
Number of pages	2
Journal	Pediatric Blood and Cancer
Volume	62
Issue number	3
DOIs	https://doi.org/10.1002/pbc.25360
State	Published - Mar 1 2015

Keywords

Osteosarcoma
Pediatric oncology
Tumors bone

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.25360

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title = "Multiple relapses in high-grade osteosarcoma: When to stop aggressive therapy?",

abstract = "The prognosis after relapse of high-grade osteosarcoma is poor and complete resection of all tumors is essential for survival. A 6-year old was diagnosed with high-grade osteosarcoma and treated according to the COSS-96 protocol. Within 5 years from initial diagnosis, five osteosarcoma relapses occurred and every time it was possible to achieve complete surgical remission. Additional treatments included chemotherapy and dendritic cell-based cancer immune therapy. Since the end of therapy of the 5th relapse, he is alive for 111/2 years. Our experience further supports that aggressive surgery can help to achieve long-term survival even in patients with multiple osteosarcoma relapses.",

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T2 - When to stop aggressive therapy?

AU - Tamamyan, Gevorg

AU - Dominkus, Martin

AU - Lang, Susanna

AU - Diakos, Christopher

AU - Mittheisz, Edda

AU - Horcher, Ernst

AU - Holter, Wolfgang

AU - Zoubek, Andreas

AU - Bielack, Stefan

AU - Kager, Leo

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N2 - The prognosis after relapse of high-grade osteosarcoma is poor and complete resection of all tumors is essential for survival. A 6-year old was diagnosed with high-grade osteosarcoma and treated according to the COSS-96 protocol. Within 5 years from initial diagnosis, five osteosarcoma relapses occurred and every time it was possible to achieve complete surgical remission. Additional treatments included chemotherapy and dendritic cell-based cancer immune therapy. Since the end of therapy of the 5th relapse, he is alive for 111/2 years. Our experience further supports that aggressive surgery can help to achieve long-term survival even in patients with multiple osteosarcoma relapses.

AB - The prognosis after relapse of high-grade osteosarcoma is poor and complete resection of all tumors is essential for survival. A 6-year old was diagnosed with high-grade osteosarcoma and treated according to the COSS-96 protocol. Within 5 years from initial diagnosis, five osteosarcoma relapses occurred and every time it was possible to achieve complete surgical remission. Additional treatments included chemotherapy and dendritic cell-based cancer immune therapy. Since the end of therapy of the 5th relapse, he is alive for 111/2 years. Our experience further supports that aggressive surgery can help to achieve long-term survival even in patients with multiple osteosarcoma relapses.

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Multiple relapses in high-grade osteosarcoma: When to stop aggressive therapy?

Abstract

Keywords

ASJC Scopus subject areas

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