TY - JOUR
T1 - Multiple unrelated translocations in a metastatic epimyoepithelial carcinoma of the parotid gland
AU - El-Naggar, Adel K.
AU - Lovell, Mercedes
AU - Ordonez, Nelson G.
AU - Killary, Ann M.
PY - 1998/1/15
Y1 - 1998/1/15
N2 - We report the cytogenetic, fluorescence in-situ hybridization (FISH) and DNA flow cytometric analysis of a rare metastatic epimyoepithelial carcinoma of the parotid gland to the lung with a clinical course of 29 years. DNA content and FISH analyses of tumor and short-term culture cells showed diploid DNA content and lack of numerical chromosomal abnormalities. Immunohistochemical analysis of the short-term culture cells showed predominantly keratin positive and sparse desmin staining supporting on epithelial rather than myoepithelial origin. Cytogenetic analysis showed 46,XY karyotype with clonal translocations of t(3;22)(q13,2;q13.1], t(1;7)(q21;q22), t(8;9)(p10,7310), and t(5;6) (q35;q21). Our findings indicate that these alterations developed in a diploid stemline during tumor progression and in the epithelial component of this tumor.
AB - We report the cytogenetic, fluorescence in-situ hybridization (FISH) and DNA flow cytometric analysis of a rare metastatic epimyoepithelial carcinoma of the parotid gland to the lung with a clinical course of 29 years. DNA content and FISH analyses of tumor and short-term culture cells showed diploid DNA content and lack of numerical chromosomal abnormalities. Immunohistochemical analysis of the short-term culture cells showed predominantly keratin positive and sparse desmin staining supporting on epithelial rather than myoepithelial origin. Cytogenetic analysis showed 46,XY karyotype with clonal translocations of t(3;22)(q13,2;q13.1], t(1;7)(q21;q22), t(8;9)(p10,7310), and t(5;6) (q35;q21). Our findings indicate that these alterations developed in a diploid stemline during tumor progression and in the epithelial component of this tumor.
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U2 - 10.1016/S0165-4608(97)00027-7
DO - 10.1016/S0165-4608(97)00027-7
M3 - Article
C2 - 9428361
AN - SCOPUS:0342782289
SN - 0165-4608
VL - 100
SP - 155
EP - 158
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -