Multispectral digital colposcopy for in vivo detection of cervical cancer

Juan Manuel Benavides; Sung Chang; Sun Young Park; Rebecca Richards-Kortum; Nick Mackinnon; Calum MacAulay; Andrea Milbourne; Anais Malpica; Michele Follen

doi:10.1364/OE.11.001223

Multispectral digital colposcopy for in vivo detection of cervical cancer

Juan Manuel Benavides, Sung Chang, Sun Young Park, Rebecca Richards-Kortum, Nick Mackinnon, Calum MacAulay, Andrea Milbourne, Anais Malpica, Michele Follen

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

We present a multispectral digital colposcope (MDC) to measure multispectral autofluorescence and reflectance images of the cervix by using an inexpensive color CCD camera. The diagnostic ability of the MDC was evaluated by application of MDC spectral response to fluorescence and reflectance spectra measured from a large clinical trial. High diagnostic performance was achieved by use of only two excitation wavelengths: 330 and 440 nm. Good quality autofluorescence images of the human cervix were acquired in vivo with the MDC. Automated diagnostic algorithms correctly identified CIN (cervical intraepithelial neoplasia) lesions from MDC fluorescence images. The MDC has the potential to provide a cost-effective alternative to standard colposcopy and better direction of biopsies.

Original language	English (US)
Pages (from-to)	1223-1236
Number of pages	14
Journal	Optics Express
Volume	11
Issue number	10
DOIs	https://doi.org/10.1364/OE.11.001223
State	Published - May 2003

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics

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abstract = "We present a multispectral digital colposcope (MDC) to measure multispectral autofluorescence and reflectance images of the cervix by using an inexpensive color CCD camera. The diagnostic ability of the MDC was evaluated by application of MDC spectral response to fluorescence and reflectance spectra measured from a large clinical trial. High diagnostic performance was achieved by use of only two excitation wavelengths: 330 and 440 nm. Good quality autofluorescence images of the human cervix were acquired in vivo with the MDC. Automated diagnostic algorithms correctly identified CIN (cervical intraepithelial neoplasia) lesions from MDC fluorescence images. The MDC has the potential to provide a cost-effective alternative to standard colposcopy and better direction of biopsies.",

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AU - Benavides, Juan Manuel

AU - Chang, Sung

AU - Park, Sun Young

AU - Richards-Kortum, Rebecca

AU - Mackinnon, Nick

AU - MacAulay, Calum

AU - Milbourne, Andrea

AU - Malpica, Anais

AU - Follen, Michele

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Multispectral digital colposcopy for in vivo detection of cervical cancer

Abstract

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