Mutagenicity of the non-carcinogenic dibenzylnitrosamine and an alpha-acetoxy derivative

Myron K. Jacobson, Rodney A. Barton, Sharon S. Yoder, Sujan Sigh, Robert E. Lyle

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The mutagenicity of a non-carcinogenic nitrosamine, N,N-dibenzylnitrcsamine (I), and a chemically synthesized α-acetoxy derivative, N-(α-acetoxybenzyl)-N-benzylnitrosamine (II), has been examined in Salmonella typhimurium TA100 and TA1535. Compound (I) was non-mutagenic when tested directly or in the presence of a metabolic activation system while (II) was highly mutagenic when tested directly. This is the first report of the conversion of a non-mutagenic N-nitrosamine to a mutagen by the formation of an α-acetoxy derivative.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalCancer Letters
Volume6
Issue number2
DOIs
StatePublished - Feb 1979
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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