Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism

Ge Zhou; Jeffrey N. Myers

doi:10.4161/23723548.2014.963441

Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism

Ge Zhou, Jeffrey N. Myers

Head & Neck Surgery

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4 Scopus citations

Abstract

The metabolic function of p53 is important for its oncosuppressive function. Mutant p53 (mutp53) with gain of oncogenic function can regulate cell metabolism. Our recent study revealed a novel transcription-independent mechanism for a gain-of-function mutp53 that directly inhibits activation of adenosine monophosphate-activated protein kinase (AMPK) to promote cancer cell metabolism.

Original language	English (US)
Article number	e963441
Journal	Molecular and Cellular Oncology
Volume	1
Issue number	3
DOIs	https://doi.org/10.4161/23723548.2014.963441
State	Published - Sep 15 2014

Keywords

AMPK
gain of function
metabolism
mutant p53
p53
p53 mutation

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.4161/23723548.2014.963441

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title = "Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism",

abstract = "The metabolic function of p53 is important for its oncosuppressive function. Mutant p53 (mutp53) with gain of oncogenic function can regulate cell metabolism. Our recent study revealed a novel transcription-independent mechanism for a gain-of-function mutp53 that directly inhibits activation of adenosine monophosphate-activated protein kinase (AMPK) to promote cancer cell metabolism.",

keywords = "AMPK, gain of function, metabolism, mutant p53, p53, p53 mutation",

author = "Ge Zhou and Myers, {Jeffrey N.}",

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AU - Myers, Jeffrey N.

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AB - The metabolic function of p53 is important for its oncosuppressive function. Mutant p53 (mutp53) with gain of oncogenic function can regulate cell metabolism. Our recent study revealed a novel transcription-independent mechanism for a gain-of-function mutp53 that directly inhibits activation of adenosine monophosphate-activated protein kinase (AMPK) to promote cancer cell metabolism.

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KW - metabolism

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KW - p53

KW - p53 mutation

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Mutant p53 exerts oncogenic functions by modulating cancer cell metabolism

Abstract

Keywords

ASJC Scopus subject areas

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