TY - JOUR
T1 - Myc and Max
T2 - a putative transcriptional complex in search of a cellular target
AU - Torres, Richard
AU - Schreiber-Agus, Nicole
AU - Morgenbesser, Sharon D.
AU - DePinho, Ronald A.
N1 - Funding Information:
and SDM are supported by NM training grant CAO9173-14. NS-A is supported by NIH training grant T32 GM07128. RAD is supported by NIH grants ROl EYO9300-01 and ROl HD28317-01, is a recipient of the McDonnell Foundation Scholar Award and a Cancer Research Institute Investigator Award and is aided by the Basil O’Connor Starter Scholar Re.search Award no. 5-724 through funds received from the Lifespring Foundation to the March of Dimes Defects Foundation.
PY - 1992/6
Y1 - 1992/6
N2 - Biochemical and genetic observations have supported the hypothesis that Myc family proteins function to regulate genes important in cellular growth and differentiation. The recent findings that Myc proteins can associate with other cellular proteins, possess sequence-specific DNA-binding activity and may directly transactivate transcription of several candidate genes have provided an experimental framework in which to test the transcription factor model. Based on principles established for several well characterized viral oncoproteins, a model is presented in which the regulation of Myc function is controlled by specific cellular protein interactions that serve to activate or repress transactivation activity or deny access of the Myc complex to its target sequences.
AB - Biochemical and genetic observations have supported the hypothesis that Myc family proteins function to regulate genes important in cellular growth and differentiation. The recent findings that Myc proteins can associate with other cellular proteins, possess sequence-specific DNA-binding activity and may directly transactivate transcription of several candidate genes have provided an experimental framework in which to test the transcription factor model. Based on principles established for several well characterized viral oncoproteins, a model is presented in which the regulation of Myc function is controlled by specific cellular protein interactions that serve to activate or repress transactivation activity or deny access of the Myc complex to its target sequences.
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U2 - 10.1016/0955-0674(92)90013-3
DO - 10.1016/0955-0674(92)90013-3
M3 - Article
C2 - 1497918
AN - SCOPUS:0026878339
SN - 0955-0674
VL - 4
SP - 468
EP - 474
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 3
ER -