Abstract
Postradiation cutaneous angiosarcoma of the breast is a rare, delayed complication of adjuvant radiation treatment for breast carcinoma and is associated with a worse prognosis than the original primary cancer. Recent studies have characterized the diagnostic utility of MYC and NOTCH1 receptor expression as markers for secondary radiation-associated angiosarcomas. Herein, we report an exophytic secondary breast angiosarcoma with MYC and NOTCH1 immunoreactivity. This case illustrates the utility of these markers for the identification of radiation-associated angiosarcoma with MYC and NOTCH1 expression, potential for targeted therapy and need to identify patients for further studies of the clinicopathologic and prognostic significance.
Original language | English (US) |
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Pages (from-to) | 264-267 |
Number of pages | 4 |
Journal | Breast Journal |
Volume | 27 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2021 |
Keywords
- MYC
- NOTCH1
- angiosarcoma
- breast carcinoma
ASJC Scopus subject areas
- Internal Medicine
- Surgery
- Oncology