TY - JOUR
T1 - Myelin lipid metabolism and its role in myelination and myelin maintenance
AU - Barnes-Vélez, Joseph A.
AU - Aksoy Yasar, Fatma Betul
AU - Hu, Jian
N1 - Publisher Copyright:
© 2022 The Author(s)
PY - 2023/1/30
Y1 - 2023/1/30
N2 - Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of membrane lipids is one of myelin's salient features that contribute to its unique role as an insulator that electrically isolates nerve fibers across their myelinated surface. The most abundant lipids in myelin include cholesterol, glycosphingolipids, and plasmalogens, each playing critical roles in myelin development as well as function. This review serves to summarize the role of lipid metabolism in myelination and myelin maintenance, as well as the molecular determinants of myelin lipid homeostasis, with an emphasis on findings from genetic models. In addition, the implications of myelin lipid dysmetabolism in human diseases are highlighted in the context of hereditary leukodystrophies and neuropathies as well as acquired disorders such as Alzheimer's disease.
AB - Myelin is a specialized cell membrane indispensable for rapid nerve conduction. The high abundance of membrane lipids is one of myelin's salient features that contribute to its unique role as an insulator that electrically isolates nerve fibers across their myelinated surface. The most abundant lipids in myelin include cholesterol, glycosphingolipids, and plasmalogens, each playing critical roles in myelin development as well as function. This review serves to summarize the role of lipid metabolism in myelination and myelin maintenance, as well as the molecular determinants of myelin lipid homeostasis, with an emphasis on findings from genetic models. In addition, the implications of myelin lipid dysmetabolism in human diseases are highlighted in the context of hereditary leukodystrophies and neuropathies as well as acquired disorders such as Alzheimer's disease.
UR - http://www.scopus.com/inward/record.url?scp=85144577118&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85144577118&partnerID=8YFLogxK
U2 - 10.1016/j.xinn.2022.100360
DO - 10.1016/j.xinn.2022.100360
M3 - Review article
C2 - 36588745
AN - SCOPUS:85144577118
SN - 2666-6758
VL - 4
JO - Innovation
JF - Innovation
IS - 1
M1 - 100360
ER -