TY - JOUR
T1 - Myelodysplastic syndrome following successful therapy of acute promyelocytic leukemia
AU - Bseiso, A. W.
AU - Kantarjian, H.
AU - Estey, E.
PY - 1997
Y1 - 1997
N2 - We describe a patient with acute promyelocytic leukemia (APL) who was successfully induced into remission with all-trans retinoic acid (ATRA) and idarubicin, but developed myelodysplastic syndrome (MDS) with monosomy 7 shortly after conclusion of maintenance therapy with idarubicin alternating with 6-mercaptopurine, vincristine, methotrexate and prednisone. Patients on combination regimens of ATRA or other retinoids and chemotherapy, which are being increasingly used in recent years, should be closely monitored for the development of potentially new complications including MDS.
AB - We describe a patient with acute promyelocytic leukemia (APL) who was successfully induced into remission with all-trans retinoic acid (ATRA) and idarubicin, but developed myelodysplastic syndrome (MDS) with monosomy 7 shortly after conclusion of maintenance therapy with idarubicin alternating with 6-mercaptopurine, vincristine, methotrexate and prednisone. Patients on combination regimens of ATRA or other retinoids and chemotherapy, which are being increasingly used in recent years, should be closely monitored for the development of potentially new complications including MDS.
KW - Acute promyelocytic leukemia
KW - Secondary myelodysplastic syndrome
UR - http://www.scopus.com/inward/record.url?scp=0031047668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031047668&partnerID=8YFLogxK
U2 - 10.1038/sj.leu.2400539
DO - 10.1038/sj.leu.2400539
M3 - Article
C2 - 9001434
AN - SCOPUS:0031047668
SN - 0887-6924
VL - 11
SP - 168
EP - 169
JO - Leukemia
JF - Leukemia
IS - 1
ER -