TY - JOUR
T1 - Myelodysplastic Syndromes
T2 - Laboratory Workup in the Context of New Concepts and Classification Criteria
AU - Sanz-De Pedro, Maria
AU - Wang, Wei
AU - Kanagal-Shamanna, Rashmi
AU - Khoury, Joseph D.
N1 - Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Purpose of Review: This review provides a comprehensive update of myelodysplastic syndromes (MDS) and their diagnostic criteria, with emphasis on novel concepts and state-of-the-art laboratory workup, including multiparameter/multicolor flow cytometry, chromosome analysis, and mutation profiling. Recent Findings: Recent advances in genetics and molecular technologies have provided unprecedented insights into the pathogenic mechanisms and genomic landscape of MDS and its precursor lesions. This has resulted in revised diagnostic criteria in the World Health Organization (WHO) classification and proposed new terminology for early lesions such as clonal hematopoiesis of indeterminate potential (CHIP). Against this landscape, a thorough understanding of the advantages and limitations of laboratory tests employed in the evaluation of patients with cytopenia has gained unprecedented importance. Summary: Healthcare providers involved in the care of patients with hematologic diseases should be aware of the intricacies of laboratory workup of such patients, particularly in view of the novel concepts and classification criteria of MDS.
AB - Purpose of Review: This review provides a comprehensive update of myelodysplastic syndromes (MDS) and their diagnostic criteria, with emphasis on novel concepts and state-of-the-art laboratory workup, including multiparameter/multicolor flow cytometry, chromosome analysis, and mutation profiling. Recent Findings: Recent advances in genetics and molecular technologies have provided unprecedented insights into the pathogenic mechanisms and genomic landscape of MDS and its precursor lesions. This has resulted in revised diagnostic criteria in the World Health Organization (WHO) classification and proposed new terminology for early lesions such as clonal hematopoiesis of indeterminate potential (CHIP). Against this landscape, a thorough understanding of the advantages and limitations of laboratory tests employed in the evaluation of patients with cytopenia has gained unprecedented importance. Summary: Healthcare providers involved in the care of patients with hematologic diseases should be aware of the intricacies of laboratory workup of such patients, particularly in view of the novel concepts and classification criteria of MDS.
KW - Classification
KW - Cytogenetics
KW - Molecular diagnostics
KW - Morphology
KW - Mutation
KW - Myelodysplastic syndrome
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U2 - 10.1007/s11899-018-0483-5
DO - 10.1007/s11899-018-0483-5
M3 - Review article
C2 - 30338456
AN - SCOPUS:85055473353
SN - 1558-8211
VL - 13
SP - 467
EP - 476
JO - Current hematologic malignancy reports
JF - Current hematologic malignancy reports
IS - 6
ER -