Myeloid sarcoma of the small bowel associated with a CBFβ/MYH11 fusion and inv(16)(p13q22): A case report

M. McKenna; C. Arnold; M. A. Catherwood; M. W. Humphreys; R. J.G. Cuthbert; C. Bueso-Ramos; Damian T. McManus

doi:10.1136/jcp.2008.063669

Myeloid sarcoma of the small bowel associated with a CBFβ/MYH11 fusion and inv(16)(p13q22): A case report

M. McKenna, C. Arnold, M. A. Catherwood, M. W. Humphreys, R. J.G. Cuthbert, C. Bueso-Ramos, Damian T. McManus

Hematopathology

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12 Scopus citations

Abstract

This report describes a case of aleukaemic myeloid sarcoma of the small intestine in a 50-year-old woman presenting with small bowel obstruction. Fluorescence in situ hybridisation analysis of interphase nuclei revealed a split CBFb signal, consistent with an underlying inversion of chromosome 16, inv(16)(p13q22). The resultant type A CBFb/MYH11 transcript was detected by reverse transcriptase PCR. Immunohistochemistry with the AH107 antibody to the CBFb-SMMHC chimeric protein showed strong nuclear staining of the tumour cell nuclei. This represents the first use of this antibody in the diagnosis of this subtype of myeloid sarcoma in the small intestine.

Original language	English (US)
Pages (from-to)	757-759
Number of pages	3
Journal	Journal of Clinical Pathology
Volume	62
Issue number	8
DOIs	https://doi.org/10.1136/jcp.2008.063669
State	Published - Aug 2009

ASJC Scopus subject areas

Pathology and Forensic Medicine

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title = "Myeloid sarcoma of the small bowel associated with a CBFβ/MYH11 fusion and inv(16)(p13q22): A case report",

abstract = "This report describes a case of aleukaemic myeloid sarcoma of the small intestine in a 50-year-old woman presenting with small bowel obstruction. Fluorescence in situ hybridisation analysis of interphase nuclei revealed a split CBFb signal, consistent with an underlying inversion of chromosome 16, inv(16)(p13q22). The resultant type A CBFb/MYH11 transcript was detected by reverse transcriptase PCR. Immunohistochemistry with the AH107 antibody to the CBFb-SMMHC chimeric protein showed strong nuclear staining of the tumour cell nuclei. This represents the first use of this antibody in the diagnosis of this subtype of myeloid sarcoma in the small intestine.",

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T1 - Myeloid sarcoma of the small bowel associated with a CBFβ/MYH11 fusion and inv(16)(p13q22)

T2 - A case report

AU - McKenna, M.

AU - Arnold, C.

AU - Catherwood, M. A.

AU - Humphreys, M. W.

AU - Cuthbert, R. J.G.

AU - Bueso-Ramos, C.

AU - McManus, Damian T.

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N2 - This report describes a case of aleukaemic myeloid sarcoma of the small intestine in a 50-year-old woman presenting with small bowel obstruction. Fluorescence in situ hybridisation analysis of interphase nuclei revealed a split CBFb signal, consistent with an underlying inversion of chromosome 16, inv(16)(p13q22). The resultant type A CBFb/MYH11 transcript was detected by reverse transcriptase PCR. Immunohistochemistry with the AH107 antibody to the CBFb-SMMHC chimeric protein showed strong nuclear staining of the tumour cell nuclei. This represents the first use of this antibody in the diagnosis of this subtype of myeloid sarcoma in the small intestine.

AB - This report describes a case of aleukaemic myeloid sarcoma of the small intestine in a 50-year-old woman presenting with small bowel obstruction. Fluorescence in situ hybridisation analysis of interphase nuclei revealed a split CBFb signal, consistent with an underlying inversion of chromosome 16, inv(16)(p13q22). The resultant type A CBFb/MYH11 transcript was detected by reverse transcriptase PCR. Immunohistochemistry with the AH107 antibody to the CBFb-SMMHC chimeric protein showed strong nuclear staining of the tumour cell nuclei. This represents the first use of this antibody in the diagnosis of this subtype of myeloid sarcoma in the small intestine.

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Myeloid sarcoma of the small bowel associated with a CBFβ/MYH11 fusion and inv(16)(p13q22): A case report

Abstract

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