Myeloma, Amyloid, and Other Dysproteinemias

Ala Abudayyeh; Paul W. Sanders

doi:10.1016/B978-0-323-47794-9.00028-7

Myeloma, Amyloid, and Other Dysproteinemias

Ala Abudayyeh, Paul W. Sanders

General Internal Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Paraproteinemia-associated kidney diseases are complex disorders that can affect every segment of the nephron. These diseases result from deposition of monoclonal immunoglobulins or monoclonal immunoglobulin fragments that include free heavy chains and free light chains. Kidney damage from deposition of monoclonal free light chains occurs most commonly and is therefore the major focus of this review. Production, renal handling, and clinical detection of immunoglobulin light chains are described, followed by descriptions of the major associated glomerular and tubular diseases. A discussion of Waldenström macroglobulinemia is also included in this chapter.

Original language	English (US)
Title of host publication	National Kidney Foundation's Primer on Kidney Diseases
Publisher	Elsevier
Pages	274-282.e1
ISBN (Electronic)	9780323477949
ISBN (Print)	9780323510608
DOIs	https://doi.org/10.1016/B978-0-323-47794-9.00028-7
State	Published - Jan 1 2017

Keywords

acute kidney injury
amyloidosis
cast nephropathy
Fanconi syndrome
fibrillary glomerulonephritis
immunoglobulin
immunotactoid glomerulopathy
light chain
monoclonal immunoglobulin deposition disease
multiple myeloma
paraprotein
proximal tubulopathy
Waldenström macroglobulinemia

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-323-47794-9.00028-7

Cite this

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title = "Myeloma, Amyloid, and Other Dysproteinemias",

abstract = "Paraproteinemia-associated kidney diseases are complex disorders that can affect every segment of the nephron. These diseases result from deposition of monoclonal immunoglobulins or monoclonal immunoglobulin fragments that include free heavy chains and free light chains. Kidney damage from deposition of monoclonal free light chains occurs most commonly and is therefore the major focus of this review. Production, renal handling, and clinical detection of immunoglobulin light chains are described, followed by descriptions of the major associated glomerular and tubular diseases. A discussion of Waldenstr{\"o}m macroglobulinemia is also included in this chapter.",

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AU - Abudayyeh, Ala

AU - Sanders, Paul W.

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N2 - Paraproteinemia-associated kidney diseases are complex disorders that can affect every segment of the nephron. These diseases result from deposition of monoclonal immunoglobulins or monoclonal immunoglobulin fragments that include free heavy chains and free light chains. Kidney damage from deposition of monoclonal free light chains occurs most commonly and is therefore the major focus of this review. Production, renal handling, and clinical detection of immunoglobulin light chains are described, followed by descriptions of the major associated glomerular and tubular diseases. A discussion of Waldenström macroglobulinemia is also included in this chapter.

AB - Paraproteinemia-associated kidney diseases are complex disorders that can affect every segment of the nephron. These diseases result from deposition of monoclonal immunoglobulins or monoclonal immunoglobulin fragments that include free heavy chains and free light chains. Kidney damage from deposition of monoclonal free light chains occurs most commonly and is therefore the major focus of this review. Production, renal handling, and clinical detection of immunoglobulin light chains are described, followed by descriptions of the major associated glomerular and tubular diseases. A discussion of Waldenström macroglobulinemia is also included in this chapter.

KW - acute kidney injury

KW - amyloidosis

KW - cast nephropathy

KW - Fanconi syndrome

KW - fibrillary glomerulonephritis

KW - immunoglobulin

KW - immunotactoid glomerulopathy

KW - light chain

KW - monoclonal immunoglobulin deposition disease

KW - multiple myeloma

KW - paraprotein

KW - proximal tubulopathy

KW - Waldenström macroglobulinemia

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SN - 9780323510608

SP - 274-282.e1

BT - National Kidney Foundation's Primer on Kidney Diseases

PB - Elsevier

ER -

Myeloma, Amyloid, and Other Dysproteinemias

Abstract

Keywords

ASJC Scopus subject areas

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