Myoepithelium in salivary and mammary neoplasms is host-friendly

John G. Batsakis; Adel K. El-Naggar

doi:10.1097/00125480-199907000-00005

Myoepithelium in salivary and mammary neoplasms is host-friendly

John G. Batsakis, Adel K. El-Naggar

Pathology, Anatomical

Research output: Contribution to journal › Comment/debate › peer-review

25 Scopus citations

Abstract

This commentary relates to ameliorative effects of myoepithelial cells in carcinomas of salivary glands and the breast as viewed not only by proliferative characteristics, but also by laboratory experiments and clinicopathologic evidence. The tumor suppressor action of myoepithelium is, in part, associated with its matrix-synthesizing and proteinase inhibitor properties. Loss of the myoepithelial phenotype yields a more aggressive carcinoma with enhanced invasive and metastatic capability.

Original language	English (US)
Pages (from-to)	218-226
Number of pages	9
Journal	Advances in anatomic pathology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1097/00125480-199907000-00005
State	Published - Jul 1999

Keywords

Adenoid cystic carcinoma
Adenomyo-epithelioma
Breast neoplasms
Epithelial-myoepithelial carcinoma
Myoepithelium
Salivary gland neoplasms

ASJC Scopus subject areas

Anatomy
Pathology and Forensic Medicine

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10.1097/00125480-199907000-00005

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title = "Myoepithelium in salivary and mammary neoplasms is host-friendly",

abstract = "This commentary relates to ameliorative effects of myoepithelial cells in carcinomas of salivary glands and the breast as viewed not only by proliferative characteristics, but also by laboratory experiments and clinicopathologic evidence. The tumor suppressor action of myoepithelium is, in part, associated with its matrix-synthesizing and proteinase inhibitor properties. Loss of the myoepithelial phenotype yields a more aggressive carcinoma with enhanced invasive and metastatic capability.",

keywords = "Adenoid cystic carcinoma, Adenomyo-epithelioma, Breast neoplasms, Epithelial-myoepithelial carcinoma, Myoepithelium, Salivary gland neoplasms",

author = "Batsakis, {John G.} and El-Naggar, {Adel K.}",

year = "1999",

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doi = "10.1097/00125480-199907000-00005",

language = "English (US)",

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pages = "218--226",

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T1 - Myoepithelium in salivary and mammary neoplasms is host-friendly

AU - Batsakis, John G.

AU - El-Naggar, Adel K.

PY - 1999/7

Y1 - 1999/7

N2 - This commentary relates to ameliorative effects of myoepithelial cells in carcinomas of salivary glands and the breast as viewed not only by proliferative characteristics, but also by laboratory experiments and clinicopathologic evidence. The tumor suppressor action of myoepithelium is, in part, associated with its matrix-synthesizing and proteinase inhibitor properties. Loss of the myoepithelial phenotype yields a more aggressive carcinoma with enhanced invasive and metastatic capability.

AB - This commentary relates to ameliorative effects of myoepithelial cells in carcinomas of salivary glands and the breast as viewed not only by proliferative characteristics, but also by laboratory experiments and clinicopathologic evidence. The tumor suppressor action of myoepithelium is, in part, associated with its matrix-synthesizing and proteinase inhibitor properties. Loss of the myoepithelial phenotype yields a more aggressive carcinoma with enhanced invasive and metastatic capability.

KW - Adenoid cystic carcinoma

KW - Adenomyo-epithelioma

KW - Breast neoplasms

KW - Epithelial-myoepithelial carcinoma

KW - Myoepithelium

KW - Salivary gland neoplasms

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U2 - 10.1097/00125480-199907000-00005

DO - 10.1097/00125480-199907000-00005

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AN - SCOPUS:0033162511

SN - 1072-4109

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JO - Advances in anatomic pathology

JF - Advances in anatomic pathology

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ER -

Myoepithelium in salivary and mammary neoplasms is host-friendly

Abstract

Keywords

ASJC Scopus subject areas

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