TY - JOUR
T1 - N‐acetylprocainamide is a less potent inducer of t cell autoreactivity than procainamide
AU - Richardson, Bruce
AU - Cornacchia, Elizabeth
AU - Golbus, Joseph
AU - Maybaum, Jonathan
AU - Strahler, John
AU - Hanash, Samir
PY - 1988/8
Y1 - 1988/8
N2 - We have reported that an inhibitor of DNA methylation, 5‐azacytidine, makes cloned, antigen‐specific CD4 + T cells autoreactive, and that procainamide and hydralazine mimic this effect. Those results suggested that procainamide and hydralazine may induce autoimmunity by inhibiting DNA methylation and causing T cell autoreactivity. We report now that N‐acetylprocainamide, a procainamide derivative that does not induce lupus, is also a DNA methylation inhibitor, but it is 100 times less potent than procainamide in inducing T cell autoreactivity.
AB - We have reported that an inhibitor of DNA methylation, 5‐azacytidine, makes cloned, antigen‐specific CD4 + T cells autoreactive, and that procainamide and hydralazine mimic this effect. Those results suggested that procainamide and hydralazine may induce autoimmunity by inhibiting DNA methylation and causing T cell autoreactivity. We report now that N‐acetylprocainamide, a procainamide derivative that does not induce lupus, is also a DNA methylation inhibitor, but it is 100 times less potent than procainamide in inducing T cell autoreactivity.
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U2 - 10.1002/art.1780310809
DO - 10.1002/art.1780310809
M3 - Article
C2 - 2457378
AN - SCOPUS:0023802405
SN - 0004-3591
VL - 31
SP - 995
EP - 999
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 8
ER -