Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency

Fernando Benavides; Mirta Giordano; Laurence Fiette; Ana Lúcia Bueno Brunialti; Natalia Martin Palenzuela; Silvia Vanzulli; Pablo Baldi; Reiner Schmidt; Christiane Dosne Pasqualini; Jean Louis Guénet

doi:10.1007/s002510050514

Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency

Fernando Benavides, Mirta Giordano, Laurence Fiette, Ana Lúcia Bueno Brunialti, Natalia Martin Palenzuela, Silvia Vanzulli, Pablo Baldi, Reiner Schmidt, Christiane Dosne Pasqualini, Jean Louis Guénet

Epigenetics & Molecular Carcinogenesis

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A spontaneous recessive mutation named nackt (symbol: nkt) affecting hair growth and T-cell development was discovered in a moderately inbred stock of mice. Skin lesions were characterized by sparse rough coat, bare patches around the eyes and neck, and a scratching behavior throughout life. Fluorescence-activated cell sorter analysis indicated a deficiency in the CD4⁺ 8^- T-cell subset in the thymus and a marked decrease in CD4⁺ T cells in peripheral lymphoid organs. Linkage analysis using a set of molecular markers and an F₂ intersubspecific cross indicated that the mutation maps to the central region of mouse chromosome 13, in a region homologous to human chromosome 5q22-q35.

Original language	English (US)
Pages (from-to)	413-419
Number of pages	7
Journal	Immunogenetics
Volume	49
Issue number	5
DOIs	https://doi.org/10.1007/s002510050514
State	Published - 1999

Keywords

CD4+ deficiency
Hair-loss mutation
Laboratory mouse

ASJC Scopus subject areas

Immunology
Genetics

Access to Document

10.1007/s002510050514

Cite this

@article{f3ffaff5387e4ff496b10d9ba85aa316,

title = "Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency",

abstract = "A spontaneous recessive mutation named nackt (symbol: nkt) affecting hair growth and T-cell development was discovered in a moderately inbred stock of mice. Skin lesions were characterized by sparse rough coat, bare patches around the eyes and neck, and a scratching behavior throughout life. Fluorescence-activated cell sorter analysis indicated a deficiency in the CD4+ 8- T-cell subset in the thymus and a marked decrease in CD4+ T cells in peripheral lymphoid organs. Linkage analysis using a set of molecular markers and an F2 intersubspecific cross indicated that the mutation maps to the central region of mouse chromosome 13, in a region homologous to human chromosome 5q22-q35.",

keywords = "CD4+ deficiency, Hair-loss mutation, Laboratory mouse",

author = "Fernando Benavides and Mirta Giordano and Laurence Fiette and {Bueno Brunialti}, {Ana L{\'u}cia} and {Martin Palenzuela}, Natalia and Silvia Vanzulli and Pablo Baldi and Reiner Schmidt and {Dosne Pasqualini}, Christiane and Gu{\'e}net, {Jean Louis}",

year = "1999",

doi = "10.1007/s002510050514",

language = "English (US)",

volume = "49",

pages = "413--419",

journal = "Immunogenetics",

issn = "0093-7711",

publisher = "Springer Verlag",

number = "5",

}

TY - JOUR

T1 - Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency

AU - Benavides, Fernando

AU - Giordano, Mirta

AU - Fiette, Laurence

AU - Bueno Brunialti, Ana Lúcia

AU - Martin Palenzuela, Natalia

AU - Vanzulli, Silvia

AU - Baldi, Pablo

AU - Schmidt, Reiner

AU - Dosne Pasqualini, Christiane

AU - Guénet, Jean Louis

PY - 1999

Y1 - 1999

N2 - A spontaneous recessive mutation named nackt (symbol: nkt) affecting hair growth and T-cell development was discovered in a moderately inbred stock of mice. Skin lesions were characterized by sparse rough coat, bare patches around the eyes and neck, and a scratching behavior throughout life. Fluorescence-activated cell sorter analysis indicated a deficiency in the CD4+ 8- T-cell subset in the thymus and a marked decrease in CD4+ T cells in peripheral lymphoid organs. Linkage analysis using a set of molecular markers and an F2 intersubspecific cross indicated that the mutation maps to the central region of mouse chromosome 13, in a region homologous to human chromosome 5q22-q35.

AB - A spontaneous recessive mutation named nackt (symbol: nkt) affecting hair growth and T-cell development was discovered in a moderately inbred stock of mice. Skin lesions were characterized by sparse rough coat, bare patches around the eyes and neck, and a scratching behavior throughout life. Fluorescence-activated cell sorter analysis indicated a deficiency in the CD4+ 8- T-cell subset in the thymus and a marked decrease in CD4+ T cells in peripheral lymphoid organs. Linkage analysis using a set of molecular markers and an F2 intersubspecific cross indicated that the mutation maps to the central region of mouse chromosome 13, in a region homologous to human chromosome 5q22-q35.

KW - CD4+ deficiency

KW - Hair-loss mutation

KW - Laboratory mouse

UR - http://www.scopus.com/inward/record.url?scp=0032898557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032898557&partnerID=8YFLogxK

U2 - 10.1007/s002510050514

DO - 10.1007/s002510050514

M3 - Article

C2 - 10199917

AN - SCOPUS:0032898557

SN - 0093-7711

VL - 49

SP - 413

EP - 419

JO - Immunogenetics

JF - Immunogenetics

IS - 5

ER -

Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this