TY - JOUR
T1 - Nano-sized ultrasound contrast agents for cancer therapy and theranostics
AU - Li, Hao
AU - Gan, Shenglong
AU - Feng, Shi Ting
AU - Zhou, Guofu
AU - Dong, Zhi
AU - Zheng, Rongqin
AU - Li, Zi Ping
N1 - Publisher Copyright:
© 2017 Bentham Science Publishers.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Ultrasound contrast agents (UCA) represented by gas-filled microbubble, can provide simultaneous and co-localized enhancement on image contrast to help disease diagnosis by highlighting tissue borders. Nowadays, Some UCAs (e.g. Levovist®, Optison®, Definity®, and Sonovue®) are commercially available, and have been clinically utilized for enhanced ultrasonography in the US, Canada, Europe, Asia and so on. However, their large diameters (1~10 μm) mainly hinder more precise and deeper applications in the imaging of capillary-abundant organs or tissues (e.g. tumor), and undersized nanoscale UCAs also lack enough backscattering echo intensity to distinguish abnormal distribution of vessels. So novel shapes, structures and materials of nano-sized UCAs are constantly emerging for cancer ultrasonic imaging. Particularly, the cavitation effect of diagnostic ultrasound can accelerate effusion of loaded contents from UCAs, following cellular uptake. This will inevitably contribute to develop other potential applications of nano-sized UCAs towards cancer therapy and theranostics.
AB - Ultrasound contrast agents (UCA) represented by gas-filled microbubble, can provide simultaneous and co-localized enhancement on image contrast to help disease diagnosis by highlighting tissue borders. Nowadays, Some UCAs (e.g. Levovist®, Optison®, Definity®, and Sonovue®) are commercially available, and have been clinically utilized for enhanced ultrasonography in the US, Canada, Europe, Asia and so on. However, their large diameters (1~10 μm) mainly hinder more precise and deeper applications in the imaging of capillary-abundant organs or tissues (e.g. tumor), and undersized nanoscale UCAs also lack enough backscattering echo intensity to distinguish abnormal distribution of vessels. So novel shapes, structures and materials of nano-sized UCAs are constantly emerging for cancer ultrasonic imaging. Particularly, the cavitation effect of diagnostic ultrasound can accelerate effusion of loaded contents from UCAs, following cellular uptake. This will inevitably contribute to develop other potential applications of nano-sized UCAs towards cancer therapy and theranostics.
KW - Cancer theranostics
KW - Cancer therapy
KW - Nano-sized
KW - Polymer
KW - Ultrasound contrast agents
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U2 - 10.2174/1381612823666170710120631
DO - 10.2174/1381612823666170710120631
M3 - Review article
C2 - 28699518
AN - SCOPUS:85042765330
SN - 1381-6128
VL - 23
SP - 5403
EP - 5412
JO - Current pharmaceutical design
JF - Current pharmaceutical design
IS - 35
ER -