TY - JOUR
T1 - Nanomedicine
T2 - Ushering in a new era of pain management
AU - Sprintz, Michael
AU - Tasciotti, Ennio
AU - Allegri, Massimo
AU - Grattoni, Alessandro
AU - Driver, Larry C.
AU - Ferrari, Mauro
N1 - Funding Information:
Financial support was received from the following sources: National Institutes of Health (NIH) Grants U54CA143837 , RO1CA128797 , and R33CA122864 ; Department of Defense Grants DODW81XWH-09-1-0212 and DODW81XWH-07-2-0101 ; and the State of Texas Emerging Technology Fund . In addition, The content is solely the responsibility of the authors and does not necessarily represent the official views of the NCRR or the NIH. The authors also disclose a personal financial interest in Leonardo Biosystems (M.F., E.T.), Nanomedical Systems (M.F., A.G.), and Arrowhead Research Corporation (M.F.). L.D, M.S., nor M.A. have any conflicts of interest or Financial arrangement relative to this article.
PY - 2011/11
Y1 - 2011/11
N2 - Pain, be it acute, chronic, or any permutation thereof, is a universal problem affecting greater than 1.5. billion people worldwide, with over 116. million in the US, and over 164 million people in Europe and Israel combined. The economic cost to society is staggering, estimated around $560-635. billion annually in the US alone for direct medical treatment costs and lost productivity. Additional complications may include over-prescribing of opiates and other potentially habit-forming substances with life-threatening side effects, as well as drug diversion and the social problems associated with substance abuse and addiction, such as illegal " pill mills," which contributed to the approximate 600% increase in opioid prescribing in the United States from 1997 to 2007, and a 300% increase in the number of deaths related to prescription opioids.However, the greatest cost of pain rests on the individual who, in addition to his or her pain, is fraught with anxiety, depression, sleep disturbances, and deteriorating interpersonal relationships, resulting in a severely diminished quality of life. While efforts are continuing to unlock the environmental and intrinsic causes and contributors to pain, there are still a great number of unmet needs throughout the realm of pain management, including imaging, drug monitoring, objective pain assessment tools, and of course, therapeutic interventions.As the technological revolution of 21st century medicine continues its ascent, nanomedicine offers unprecedented opportunities in the development of novel pain assessment, diagnostic, and therapeutic delivery mechanisms that will address many of the global unmet needs in pain management, and change the frowning face of pain to a smile of relief. Successful integration of nanomedicine into the clinical milieu requires multi- and interdisciplinary collaboration from every facet, including healthcare professionals, engineers, scientists and researchers, government and regulatory agencies as well as academia.
AB - Pain, be it acute, chronic, or any permutation thereof, is a universal problem affecting greater than 1.5. billion people worldwide, with over 116. million in the US, and over 164 million people in Europe and Israel combined. The economic cost to society is staggering, estimated around $560-635. billion annually in the US alone for direct medical treatment costs and lost productivity. Additional complications may include over-prescribing of opiates and other potentially habit-forming substances with life-threatening side effects, as well as drug diversion and the social problems associated with substance abuse and addiction, such as illegal " pill mills," which contributed to the approximate 600% increase in opioid prescribing in the United States from 1997 to 2007, and a 300% increase in the number of deaths related to prescription opioids.However, the greatest cost of pain rests on the individual who, in addition to his or her pain, is fraught with anxiety, depression, sleep disturbances, and deteriorating interpersonal relationships, resulting in a severely diminished quality of life. While efforts are continuing to unlock the environmental and intrinsic causes and contributors to pain, there are still a great number of unmet needs throughout the realm of pain management, including imaging, drug monitoring, objective pain assessment tools, and of course, therapeutic interventions.As the technological revolution of 21st century medicine continues its ascent, nanomedicine offers unprecedented opportunities in the development of novel pain assessment, diagnostic, and therapeutic delivery mechanisms that will address many of the global unmet needs in pain management, and change the frowning face of pain to a smile of relief. Successful integration of nanomedicine into the clinical milieu requires multi- and interdisciplinary collaboration from every facet, including healthcare professionals, engineers, scientists and researchers, government and regulatory agencies as well as academia.
KW - Chronic pain
KW - Drug delivery
KW - Nanochannel
KW - Nanomedicine
KW - Nanoparticle
KW - Nerve repair
KW - Pain
KW - Regeneration
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U2 - 10.1016/j.eujps.2011.08.004
DO - 10.1016/j.eujps.2011.08.004
M3 - Article
AN - SCOPUS:83355171235
SN - 1754-3207
VL - 5
SP - 317
EP - 322
JO - European Journal of Pain Supplements
JF - European Journal of Pain Supplements
IS - 2
ER -