Natural and recombinant human interleukin 1-β is cytotoxic for human melanoma cells

L. B. Lachman; C. A. Dinarello; N. D. Llansa; I. J. Fidler

Natural and recombinant human interleukin 1-β is cytotoxic for human melanoma cells

L. B. Lachman, C. A. Dinarello, N. D. Llansa, I. J. Fidler

Cancer Biology

Research output: Contribution to journal › Article › peer-review

214 Scopus citations

Abstract

Human peripheral blood monocytes stimulated with LPS were found to release an activity that was cytotoxic for the A375 melanoma. Biochemical and immunological characterization of the activity indicated that IL 1-β was the cytotoxic agent. Human recombinant IL 1-β, purified to homogeneity, was directly cytotoxic for A375. Tumor necrosis factor, also released by activated monocytes, was not cytotoxic for the A375 melanoma.

Original language	English (US)
Pages (from-to)	3098-3102
Number of pages	5
Journal	Journal of Immunology
Volume	136
Issue number	8
State	Published - 1986

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Cite this

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title = "Natural and recombinant human interleukin 1-β is cytotoxic for human melanoma cells",

abstract = "Human peripheral blood monocytes stimulated with LPS were found to release an activity that was cytotoxic for the A375 melanoma. Biochemical and immunological characterization of the activity indicated that IL 1-β was the cytotoxic agent. Human recombinant IL 1-β, purified to homogeneity, was directly cytotoxic for A375. Tumor necrosis factor, also released by activated monocytes, was not cytotoxic for the A375 melanoma.",

author = "Lachman, {L. B.} and Dinarello, {C. A.} and Llansa, {N. D.} and Fidler, {I. J.}",

year = "1986",

language = "English (US)",

volume = "136",

pages = "3098--3102",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

number = "8",

}

TY - JOUR

T1 - Natural and recombinant human interleukin 1-β is cytotoxic for human melanoma cells

AU - Lachman, L. B.

AU - Dinarello, C. A.

AU - Llansa, N. D.

AU - Fidler, I. J.

PY - 1986

Y1 - 1986

N2 - Human peripheral blood monocytes stimulated with LPS were found to release an activity that was cytotoxic for the A375 melanoma. Biochemical and immunological characterization of the activity indicated that IL 1-β was the cytotoxic agent. Human recombinant IL 1-β, purified to homogeneity, was directly cytotoxic for A375. Tumor necrosis factor, also released by activated monocytes, was not cytotoxic for the A375 melanoma.

AB - Human peripheral blood monocytes stimulated with LPS were found to release an activity that was cytotoxic for the A375 melanoma. Biochemical and immunological characterization of the activity indicated that IL 1-β was the cytotoxic agent. Human recombinant IL 1-β, purified to homogeneity, was directly cytotoxic for A375. Tumor necrosis factor, also released by activated monocytes, was not cytotoxic for the A375 melanoma.

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M3 - Article

C2 - 3485680

AN - SCOPUS:0022622881

SN - 0022-1767

VL - 136

SP - 3098

EP - 3102

JO - Journal of Immunology

JF - Journal of Immunology

IS - 8

ER -

Natural and recombinant human interleukin 1-β is cytotoxic for human melanoma cells

Abstract

ASJC Scopus subject areas

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