NBR2: A former junk gene emerges as a key player in tumor suppression

Zhen Dong Xiao; Xiaowen Liu; Li Zhuang; Boyi Gan

doi:10.1080/23723556.2016.1187322

NBR2: A former junk gene emerges as a key player in tumor suppression

Zhen Dong Xiao, Xiaowen Liu, Li Zhuang, Boyi Gan

Experimental Radiation Oncology

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

NBR2 (neighbor of BRCA1 gene 2) is a non–protein coding gene that resides adjacent to tumor suppressor gene BRCA1, but its role in cancer biology has remained unknown. Our recent study showed that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate–activated protein kinase (AMPK) activation.

Original language	English (US)
Article number	e1187322
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2016.1187322
State	Published - Jul 3 2016

Keywords

AMPK
BRCA1
NBR2
energy stress response
lncRNA
tumor suppression

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2016.1187322

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abstract = "NBR2 (neighbor of BRCA1 gene 2) is a non–protein coding gene that resides adjacent to tumor suppressor gene BRCA1, but its role in cancer biology has remained unknown. Our recent study showed that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate–activated protein kinase (AMPK) activation.",

keywords = "AMPK, BRCA1, NBR2, energy stress response, lncRNA, tumor suppression",

author = "Xiao, {Zhen Dong} and Xiaowen Liu and Li Zhuang and Boyi Gan",

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AU - Liu, Xiaowen

AU - Zhuang, Li

AU - Gan, Boyi

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AB - NBR2 (neighbor of BRCA1 gene 2) is a non–protein coding gene that resides adjacent to tumor suppressor gene BRCA1, but its role in cancer biology has remained unknown. Our recent study showed that NBR2 encodes a long non-coding RNA and suppresses tumor development through regulation of adenosine monophosphate–activated protein kinase (AMPK) activation.

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KW - energy stress response

KW - lncRNA

KW - tumor suppression

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NBR2: A former junk gene emerges as a key player in tumor suppression

Abstract

Keywords

ASJC Scopus subject areas

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