TY - JOUR
T1 - Necrotizing mucormycosis ofwounds following combat injuries, natural disasters, burns, and other trauma
AU - Walsh, Thomas J.
AU - Hospenthal, Duane R.
AU - Petraitis, Vidmantas
AU - Kontoyiannis, Dimitrios P.
N1 - Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2019/9
Y1 - 2019/9
N2 - Necrotizing mucormycosis is a devastating complication of wounds incurred in the setting of military (combat) injuries, natural disasters, burns, or other civilian trauma. Apophysomyces species, Saksenaea species and Lichtheimia (formerly Absidia) species, although uncommon as causes of sinopulmonary mucormycosis, are relatively frequent agents of trauma-related mucormycosis. The pathogenesis of these infections likely involves a complex interaction among organism, impaired innate host defenses, and biofilms related to traumatically implanted foreign materials. Effective management depends upon timely diagnosis, thorough surgical debridement, and early initiation of antifungal therapy.
AB - Necrotizing mucormycosis is a devastating complication of wounds incurred in the setting of military (combat) injuries, natural disasters, burns, or other civilian trauma. Apophysomyces species, Saksenaea species and Lichtheimia (formerly Absidia) species, although uncommon as causes of sinopulmonary mucormycosis, are relatively frequent agents of trauma-related mucormycosis. The pathogenesis of these infections likely involves a complex interaction among organism, impaired innate host defenses, and biofilms related to traumatically implanted foreign materials. Effective management depends upon timely diagnosis, thorough surgical debridement, and early initiation of antifungal therapy.
KW - Antifungal therapy
KW - Mucormycosis
UR - http://www.scopus.com/inward/record.url?scp=85071143938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85071143938&partnerID=8YFLogxK
U2 - 10.3390/jof5030057
DO - 10.3390/jof5030057
M3 - Review article
C2 - 31277364
AN - SCOPUS:85071143938
SN - 2309-608X
VL - 5
JO - Journal of Fungi
JF - Journal of Fungi
IS - 3
M1 - 57
ER -