NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

Pranay Goel; Jantina A. Manning; Sharad Kumar

doi:10.1016/j.gene.2014.11.051

NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

Pranay Goel, Jantina A. Manning, Sharad Kumar

Lymphoma-Myeloma

Research output: Contribution to journal › Review article › peer-review

118 Scopus citations

Abstract

NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover. Several of the NEDD4-2 substrates include ion channels, such as the epithelial and voltage-gated sodium channels. Given the critical function of NEDD4-2 in regulating membrane proteins, this ligase is essential for the maintenance of cellular homeostasis. In this article we review the biology and function of this important ubiquitin-protein ligase and discuss its pathophysiological significance.

Original language	English (US)
Pages (from-to)	1-10
Number of pages	10
Journal	Gene
Volume	557
Issue number	1
DOIs	https://doi.org/10.1016/j.gene.2014.11.051
State	Published - Feb 15 2015

Keywords

Epithelial sodium channel (ENaC)
Hypertension
NEDD4 family
Ubiquitin
Ubiquitin protein ligases
Voltage-gated sodium channels (Nas)

ASJC Scopus subject areas

Genetics

Access to Document

10.1016/j.gene.2014.11.051

Cite this

@article{911f0a26acc9485e935049d2e695a83b,

title = "NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins",

abstract = "NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover. Several of the NEDD4-2 substrates include ion channels, such as the epithelial and voltage-gated sodium channels. Given the critical function of NEDD4-2 in regulating membrane proteins, this ligase is essential for the maintenance of cellular homeostasis. In this article we review the biology and function of this important ubiquitin-protein ligase and discuss its pathophysiological significance.",

keywords = "Epithelial sodium channel (ENaC), Hypertension, NEDD4 family, Ubiquitin, Ubiquitin protein ligases, Voltage-gated sodium channels (Nas)",

author = "Pranay Goel and Manning, {Jantina A.} and Sharad Kumar",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier B.V.",

year = "2015",

month = feb,

day = "15",

doi = "10.1016/j.gene.2014.11.051",

language = "English (US)",

volume = "557",

pages = "1--10",

journal = "Gene",

issn = "0378-1119",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - NEDD4-2 (NEDD4L)

T2 - The ubiquitin ligase for multiple membrane proteins

AU - Goel, Pranay

AU - Manning, Jantina A.

AU - Kumar, Sharad

PY - 2015/2/15

Y1 - 2015/2/15

N2 - NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover. Several of the NEDD4-2 substrates include ion channels, such as the epithelial and voltage-gated sodium channels. Given the critical function of NEDD4-2 in regulating membrane proteins, this ligase is essential for the maintenance of cellular homeostasis. In this article we review the biology and function of this important ubiquitin-protein ligase and discuss its pathophysiological significance.

AB - NEDD4-2 (also known as NEDD4L, neural precursor cell expressed developmentally down-regulated 4-like) is a ubiquitin protein ligase of the Nedd4 family which is known to bind and regulate a number of membrane proteins to aid in their internalization and turnover. Several of the NEDD4-2 substrates include ion channels, such as the epithelial and voltage-gated sodium channels. Given the critical function of NEDD4-2 in regulating membrane proteins, this ligase is essential for the maintenance of cellular homeostasis. In this article we review the biology and function of this important ubiquitin-protein ligase and discuss its pathophysiological significance.

KW - Epithelial sodium channel (ENaC)

KW - Hypertension

KW - NEDD4 family

KW - Ubiquitin

KW - Ubiquitin protein ligases

KW - Voltage-gated sodium channels (Nas)

UR - http://www.scopus.com/inward/record.url?scp=84920085136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920085136&partnerID=8YFLogxK

U2 - 10.1016/j.gene.2014.11.051

DO - 10.1016/j.gene.2014.11.051

M3 - Review article

C2 - 25433090

AN - SCOPUS:84920085136

SN - 0378-1119

VL - 557

SP - 1

EP - 10

JO - Gene

JF - Gene

IS - 1

ER -

NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this