Neighborhood deprivation and clinical outcomes among head and neck cancer patients

Lorraine R. Reitzel; Nga Nguyen; Mark E. Zafereo; Guojun Li; Qingyi Wei; Erich M. Sturgis

doi:10.1016/j.healthplace.2012.03.005

Neighborhood deprivation and clinical outcomes among head and neck cancer patients

Lorraine R. Reitzel, Nga Nguyen, Mark E. Zafereo, Guojun Li, Qingyi Wei, Erich M. Sturgis

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The unique effects of neighborhood-level economic deprivation on survival, recurrence, and second primary malignancy development were examined using adjusted Cox proportional hazards regression models among 1151 incident squamous cell carcinomas of the head and neck patients. Cancer site was examined as a potential moderator. Main analyses yielded null results; however, interaction analyses indicated poorer overall survival [HR=1.59 (1.00-2.53)] and greater second primary malignancy development [HR=2.99 (1.46-6.11)] among oropharyngeal cancer patients from highly deprived neighborhoods relative to less deprived neighborhoods. Results suggest a dual focus on individual and neighborhood risk factors could help improve clinical outcomes among oropharyngeal cancer patients.

Original language	English (US)
Pages (from-to)	861-868
Number of pages	8
Journal	Health and Place
Volume	18
Issue number	4
DOIs	https://doi.org/10.1016/j.healthplace.2012.03.005
State	Published - Jul 2012

Keywords

Head and neck cancer
Neighborhood deprivation
Oropharyngeal cancer
Second primary malignancy
Survival outcomes

ASJC Scopus subject areas

Health(social science)
Sociology and Political Science
Life-span and Life-course Studies

MD Anderson CCSG core facilities

Biostatistics Resource Group

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10.1016/j.healthplace.2012.03.005

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title = "Neighborhood deprivation and clinical outcomes among head and neck cancer patients",

abstract = "The unique effects of neighborhood-level economic deprivation on survival, recurrence, and second primary malignancy development were examined using adjusted Cox proportional hazards regression models among 1151 incident squamous cell carcinomas of the head and neck patients. Cancer site was examined as a potential moderator. Main analyses yielded null results; however, interaction analyses indicated poorer overall survival [HR=1.59 (1.00-2.53)] and greater second primary malignancy development [HR=2.99 (1.46-6.11)] among oropharyngeal cancer patients from highly deprived neighborhoods relative to less deprived neighborhoods. Results suggest a dual focus on individual and neighborhood risk factors could help improve clinical outcomes among oropharyngeal cancer patients.",

keywords = "Head and neck cancer, Neighborhood deprivation, Oropharyngeal cancer, Second primary malignancy, Survival outcomes",

author = "Reitzel, {Lorraine R.} and Nga Nguyen and Zafereo, {Mark E.} and Guojun Li and Qingyi Wei and Sturgis, {Erich M.}",

note = "Funding Information: Financial support. This manuscript was supported by the National Institutes of Health through The University of Texas MD Anderson's Cancer Center Support Grant (CA016672), the National Cancer Institute (R03CA128110 to EM Sturgis, K07CA133099 and R03CA135679 to G Li, and R01CA131274 to Q Wei), the National Institute of Environmental Health Sciences (R01ES011740 to Q Wei), and The University of Texas MD Anderson Cancer Center start-up funds (LR Reitzel). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or The University of Texas MD Anderson Cancer Center. ",

year = "2012",

month = jul,

doi = "10.1016/j.healthplace.2012.03.005",

language = "English (US)",

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pages = "861--868",

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AU - Nguyen, Nga

AU - Zafereo, Mark E.

AU - Li, Guojun

AU - Wei, Qingyi

AU - Sturgis, Erich M.

N1 - Funding Information: Financial support. This manuscript was supported by the National Institutes of Health through The University of Texas MD Anderson's Cancer Center Support Grant (CA016672), the National Cancer Institute (R03CA128110 to EM Sturgis, K07CA133099 and R03CA135679 to G Li, and R01CA131274 to Q Wei), the National Institute of Environmental Health Sciences (R01ES011740 to Q Wei), and The University of Texas MD Anderson Cancer Center start-up funds (LR Reitzel). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or The University of Texas MD Anderson Cancer Center.

PY - 2012/7

Y1 - 2012/7

N2 - The unique effects of neighborhood-level economic deprivation on survival, recurrence, and second primary malignancy development were examined using adjusted Cox proportional hazards regression models among 1151 incident squamous cell carcinomas of the head and neck patients. Cancer site was examined as a potential moderator. Main analyses yielded null results; however, interaction analyses indicated poorer overall survival [HR=1.59 (1.00-2.53)] and greater second primary malignancy development [HR=2.99 (1.46-6.11)] among oropharyngeal cancer patients from highly deprived neighborhoods relative to less deprived neighborhoods. Results suggest a dual focus on individual and neighborhood risk factors could help improve clinical outcomes among oropharyngeal cancer patients.

AB - The unique effects of neighborhood-level economic deprivation on survival, recurrence, and second primary malignancy development were examined using adjusted Cox proportional hazards regression models among 1151 incident squamous cell carcinomas of the head and neck patients. Cancer site was examined as a potential moderator. Main analyses yielded null results; however, interaction analyses indicated poorer overall survival [HR=1.59 (1.00-2.53)] and greater second primary malignancy development [HR=2.99 (1.46-6.11)] among oropharyngeal cancer patients from highly deprived neighborhoods relative to less deprived neighborhoods. Results suggest a dual focus on individual and neighborhood risk factors could help improve clinical outcomes among oropharyngeal cancer patients.

KW - Head and neck cancer

KW - Neighborhood deprivation

KW - Oropharyngeal cancer

KW - Second primary malignancy

KW - Survival outcomes

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Neighborhood deprivation and clinical outcomes among head and neck cancer patients

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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