TY - JOUR
T1 - Neighborhood-Level Socioeconomic Disadvantage Predicts Outcomes in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Malignancy
AU - Winicki, Nolan M.
AU - Radomski, Shannon N.
AU - Florissi, Isabella S.
AU - Cloyd, Jordan M.
AU - Gutta, Goutam
AU - Grotz, Travis E.
AU - Scally, Christopher P.
AU - Fournier, Keith F.
AU - Dineen, Sean P.
AU - Powers, Benjamin D.
AU - Veerapong, Jula
AU - Baumgartner, Joel M.
AU - Clarke, Callisia N.
AU - Kothari, Anai N.
AU - Maduekwe, Ugwuji N.
AU - Patel, Sameer H.
AU - Wilson, Gregory C.
AU - Schwartz, Patrick
AU - Varley, Patrick R.
AU - Raoof, Mustafa
AU - Lee, Byrne
AU - Malik, Ibrahim
AU - Johnston, Fabian M.
AU - Greer, Jonathan B.
N1 - Publisher Copyright:
© 2023, Society of Surgical Oncology.
PY - 2023/11
Y1 - 2023/11
N2 - Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) improves survival in select patients with peritoneal metastases (PM), but the impact of social determinants of health on CRS/HIPEC outcomes remains unclear. Patients and Methods: A retrospective review was conducted of a multi-institutional database of patients with PM who underwent CRS/HIPEC in the USA between 2000 and 2017. The area deprivation index (ADI) was linked to the patient’s residential address. Patients were categorized as living in low (1–49) or high (50–100) ADI residences, with increasing scores indicating higher socioeconomic disadvantage. The primary outcome was overall survival (OS). Secondary outcomes included perioperative complications, hospital/intensive care unit (ICU) length of stay (LOS), and disease-free survival (DFS). Results: Among 1675 patients 1061 (63.3%) resided in low ADI areas and 614 (36.7%) high ADI areas. Appendiceal tumors (n = 1102, 65.8%) and colon cancer (n = 322, 19.2%) were the most common histologies. On multivariate analysis, high ADI was not associated with increased perioperative complications, hospital/ICU LOS, or DFS. High ADI was associated with worse OS (median not reached versus 49 months; 5 year OS 61.0% versus 28.2%, P < 0.0001). On multivariate Cox-regression analysis, high ADI (HR, 2.26; 95% CI 1.13–4.50; P < 0.001), cancer recurrence (HR, 2.26; 95% CI 1.61–3.20; P < 0.0001), increases in peritoneal carcinomatosis index (HR, 1.03; 95% CI 1.01–1.05; P < 0.001), and incomplete cytoreduction (HR, 4.48; 95% CI 3.01–6.53; P < 0.0001) were associated with worse OS. Conclusions: Even after controlling for cancer-specific variables, adverse outcomes persisted in association with neighborhood-level socioeconomic disadvantage. The individual and structural-level factors leading to these cancer disparities warrant further investigation to improve outcomes for all patients with peritoneal malignancies.
AB - Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) improves survival in select patients with peritoneal metastases (PM), but the impact of social determinants of health on CRS/HIPEC outcomes remains unclear. Patients and Methods: A retrospective review was conducted of a multi-institutional database of patients with PM who underwent CRS/HIPEC in the USA between 2000 and 2017. The area deprivation index (ADI) was linked to the patient’s residential address. Patients were categorized as living in low (1–49) or high (50–100) ADI residences, with increasing scores indicating higher socioeconomic disadvantage. The primary outcome was overall survival (OS). Secondary outcomes included perioperative complications, hospital/intensive care unit (ICU) length of stay (LOS), and disease-free survival (DFS). Results: Among 1675 patients 1061 (63.3%) resided in low ADI areas and 614 (36.7%) high ADI areas. Appendiceal tumors (n = 1102, 65.8%) and colon cancer (n = 322, 19.2%) were the most common histologies. On multivariate analysis, high ADI was not associated with increased perioperative complications, hospital/ICU LOS, or DFS. High ADI was associated with worse OS (median not reached versus 49 months; 5 year OS 61.0% versus 28.2%, P < 0.0001). On multivariate Cox-regression analysis, high ADI (HR, 2.26; 95% CI 1.13–4.50; P < 0.001), cancer recurrence (HR, 2.26; 95% CI 1.61–3.20; P < 0.0001), increases in peritoneal carcinomatosis index (HR, 1.03; 95% CI 1.01–1.05; P < 0.001), and incomplete cytoreduction (HR, 4.48; 95% CI 3.01–6.53; P < 0.0001) were associated with worse OS. Conclusions: Even after controlling for cancer-specific variables, adverse outcomes persisted in association with neighborhood-level socioeconomic disadvantage. The individual and structural-level factors leading to these cancer disparities warrant further investigation to improve outcomes for all patients with peritoneal malignancies.
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U2 - 10.1245/s10434-023-14074-2
DO - 10.1245/s10434-023-14074-2
M3 - Article
C2 - 37620532
AN - SCOPUS:85168622027
SN - 1068-9265
VL - 30
SP - 7840
EP - 7847
JO - Annals of surgical oncology
JF - Annals of surgical oncology
IS - 12
ER -