Neoadjuvant Approaches to Non-Melanoma Skin Cancer

David C. Wilde; Mica E. Glaun; Michael K. Wong; Neil D. Gross

doi:10.3390/cancers15235494

Neoadjuvant Approaches to Non-Melanoma Skin Cancer

David C. Wilde, Mica E. Glaun, Michael K. Wong, Neil D. Gross

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Surgery and external-beam radiation therapy are the primary treatment modalities for locally advanced NMSC, but they can lead to impairment of function and disfigurement in sensitive areas such as the head and neck. With the advent of targeted systemic therapies and immunotherapy, physicians have explored the ability to offer neoadjuvant therapy for NMSC in order to reduce surgically induced morbidity. Provided herein is a guide to current applications of neoadjuvant systemic therapies for NMSC and future directions.

Original language	English (US)
Article number	5494
Journal	Cancers
Volume	15
Issue number	23
DOIs	https://doi.org/10.3390/cancers15235494
State	Published - Dec 2023

Keywords

Merkel cell carcinoma
basal cell carcinoma
cutaneous squamous cell carcinoma
neoadjuvant therapy
non-melanomatous skin cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3390/cancers15235494

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@article{51f53b954d5d4165928ff252a7de6457,

title = "Neoadjuvant Approaches to Non-Melanoma Skin Cancer",

abstract = "Surgery and external-beam radiation therapy are the primary treatment modalities for locally advanced NMSC, but they can lead to impairment of function and disfigurement in sensitive areas such as the head and neck. With the advent of targeted systemic therapies and immunotherapy, physicians have explored the ability to offer neoadjuvant therapy for NMSC in order to reduce surgically induced morbidity. Provided herein is a guide to current applications of neoadjuvant systemic therapies for NMSC and future directions.",

keywords = "Merkel cell carcinoma, basal cell carcinoma, cutaneous squamous cell carcinoma, neoadjuvant therapy, non-melanomatous skin cancer",

author = "Wilde, {David C.} and Glaun, {Mica E.} and Wong, {Michael K.} and Gross, {Neil D.}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2023",

month = dec,

doi = "10.3390/cancers15235494",

language = "English (US)",

volume = "15",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

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TY - JOUR

T1 - Neoadjuvant Approaches to Non-Melanoma Skin Cancer

AU - Wilde, David C.

AU - Glaun, Mica E.

AU - Wong, Michael K.

AU - Gross, Neil D.

PY - 2023/12

Y1 - 2023/12

N2 - Surgery and external-beam radiation therapy are the primary treatment modalities for locally advanced NMSC, but they can lead to impairment of function and disfigurement in sensitive areas such as the head and neck. With the advent of targeted systemic therapies and immunotherapy, physicians have explored the ability to offer neoadjuvant therapy for NMSC in order to reduce surgically induced morbidity. Provided herein is a guide to current applications of neoadjuvant systemic therapies for NMSC and future directions.

AB - Surgery and external-beam radiation therapy are the primary treatment modalities for locally advanced NMSC, but they can lead to impairment of function and disfigurement in sensitive areas such as the head and neck. With the advent of targeted systemic therapies and immunotherapy, physicians have explored the ability to offer neoadjuvant therapy for NMSC in order to reduce surgically induced morbidity. Provided herein is a guide to current applications of neoadjuvant systemic therapies for NMSC and future directions.

KW - Merkel cell carcinoma

KW - basal cell carcinoma

KW - cutaneous squamous cell carcinoma

KW - neoadjuvant therapy

KW - non-melanomatous skin cancer

UR - http://www.scopus.com/inward/record.url?scp=85179313449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85179313449&partnerID=8YFLogxK

U2 - 10.3390/cancers15235494

DO - 10.3390/cancers15235494

M3 - Review article

C2 - 38067198

AN - SCOPUS:85179313449

SN - 2072-6694

VL - 15

JO - Cancers

JF - Cancers

IS - 23

M1 - 5494

ER -

Neoadjuvant Approaches to Non-Melanoma Skin Cancer

Abstract

Keywords

ASJC Scopus subject areas

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