TY - JOUR
T1 - Neoadjuvant immunotherapy across cancers
T2 - meeting report from the Immunotherapy Bridge—December 1st–2nd, 2021
AU - Burton, Elizabeth M.
AU - Amaria, Rodabe N.
AU - Cascone, Tina
AU - Chalabi, Myriam
AU - Gross, Neil D.
AU - Mittendorf, Elizabeth A.
AU - Scolyer, Richard A.
AU - Sharma, Padmanee
AU - Ascierto, Paolo A.
N1 - Funding Information:
Elizabeth M. Burton (EMB): nothing to disclose. Rodabe N. Amaria (RNA): Research funding and advisory board: Novartis, BMS, Iovance. Tina Cascone (TC): speaker fees/honoraria: The Society for Immunotherapy of Cancer, Bristol Myers Squibb, Roche, Medscape, and PeerView; advisory role/consulting fees: MedImmune/AstraZeneca, Bristol Myers Squibb, EMD Serono, Merck & Co., Genentech, and Arrowhead Pharmaceuticals; Institutional research funding: MedImmune/AstraZeneca, Bristol Myers Squibb, and EMD Serono. Myriam Chalabi (MC): MSD, BMS, Roche-Genentech (research funding to the institute). Neil Gross (NG): Research Support, Consulting: Regeneron; Ad-hoc Scientific Advisory Board: Sanofi- Genzyme, Shattuck Labs; Scientific Advisory Board: PDS Biotechnology; Consulting: DragonFly, Intuitive Surgical; Institutional Consulting: Verb Surgical. Elizabeth A. Mittendorf (EAM): Scientific Advisory Board: AstraZeneca, Genomic Health, Merck, Peregrine Pharmaceuticals, Roche/Genentech, Sellas lifesciences, TapImmune; Clinical Trial Support (to institution): AstraZeneca, EMD Serono, Galena Biopharma, Roche/Genentech; Research Support: Glaxo SmithKline; Steering Committees: BMS, Lilly, Roche/Genentech Richard A. Scolyer (RAS): has received fees for professional services from F. Hoffmann-La Roche Ltd, Evaxion, Provectus Biopharmaceuticals Australia, Qbiotics, Novartis, Merck Sharp & Dohme, NeraCare, AMGEN Inc., Bristol-Myers Squibb, Myriad Genetics and GlaxoSmithKline. Funding: is supported by an NHMRC Practitioner Fellowship (APP1141295). Padmanee Sharma (PS): Consulting or Stock Ownership or Advisory Board: Achelois, Adaptive Biotechnologies, Affini-T, Apricity, BioAtla, BioNTech, Candel Therapeutics, Catalio, Codiak, Dragonfly, Earli, Enable Medicine, Glympse, Hummingbird, ImaginAb, Infinity Pharma, JSL Health, Lava Therapeutics, Lytix, Marker, Oncolytics, PBM Capital, Phenomic AI, Polaris Pharma, Sporos, Time Bioventures, Trained Therapeutix, Two Bear Capital, Venn Biosciences. Paolo A. Ascierto (PAA): Employment or Leadership Position: None; Consultant/Advisory Role: Bristol-Myers Squibb, Roche-Genentech, Merck Sharp & Dohme, Novartis, Merck Serono, Pierre-Fabre, AstraZeneca, Sun Pharma, Sanofi, Idera, Sandoz, Immunocore, 4SC, Italfarmaco, Nektar, Boehringer-Ingelheim, Eisai, Regeneron, Daiichi Sankyo, Pfizer, OncoSec, Nouscom, Lunaphore, Seagen, iTeos, Medicenna; Stock Ownership: None; Research Funding: Bristol-Myers Squibb, Roche-Genentech, Pfizer, Sanofi; Expert Testimony: None; Other Remuneration: None.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - After the success of immunotherapy in the treatment of advanced metastatic cancer, further evaluation in earlier settings, including high-risk, surgically-resectable disease is underway. Potential benefits of a neoadjuvant immunotherapeutic approach include presurgical tumor shrinkage, reduced surgical morbidity, early eradication of micrometastases and prevention of distant disease, and greater antigen-specific T cell response. For some cancers, pathologic response has been established as a surrogate measure for long-term outcomes, therefore offering the ability for early and objective assessment of treatment efficacy and the potential to inform and personalize adjuvant treatment clinical decision-making. Leveraging the neoadjuvant treatment setting offers the ability to deeply interrogate longitudinal tissue in order to gain translatable, pan-malignancy insights into response and mechanisms of resistance to immunotherapy. Neoadjuvant immunotherapy across cancers was a focus of discussion at the virtual Immunotherapy Bridge meeting (December 1–2, 2021). Clinical, biomarker, and pathologic insights from prostate, breast, colon, and non-small-cell lung cancers, melanoma and non-melanoma skin cancers were discussed and are summarized in this report.
AB - After the success of immunotherapy in the treatment of advanced metastatic cancer, further evaluation in earlier settings, including high-risk, surgically-resectable disease is underway. Potential benefits of a neoadjuvant immunotherapeutic approach include presurgical tumor shrinkage, reduced surgical morbidity, early eradication of micrometastases and prevention of distant disease, and greater antigen-specific T cell response. For some cancers, pathologic response has been established as a surrogate measure for long-term outcomes, therefore offering the ability for early and objective assessment of treatment efficacy and the potential to inform and personalize adjuvant treatment clinical decision-making. Leveraging the neoadjuvant treatment setting offers the ability to deeply interrogate longitudinal tissue in order to gain translatable, pan-malignancy insights into response and mechanisms of resistance to immunotherapy. Neoadjuvant immunotherapy across cancers was a focus of discussion at the virtual Immunotherapy Bridge meeting (December 1–2, 2021). Clinical, biomarker, and pathologic insights from prostate, breast, colon, and non-small-cell lung cancers, melanoma and non-melanoma skin cancers were discussed and are summarized in this report.
KW - CTLA-4
KW - Checkpoint inhibitors
KW - Immunotherapy
KW - Neoadjuvant
KW - PD-1
KW - Pathological response
UR - http://www.scopus.com/inward/record.url?scp=85132104054&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85132104054&partnerID=8YFLogxK
U2 - 10.1186/s12967-022-03472-x
DO - 10.1186/s12967-022-03472-x
M3 - Article
C2 - 35706041
AN - SCOPUS:85132104054
SN - 1479-5876
VL - 20
JO - Journal of translational medicine
JF - Journal of translational medicine
IS - 1
M1 - 271
ER -