TY - JOUR
T1 - Neural substrates of respiratory sensory gating
T2 - A human fMRI study
AU - Chan, Pei Ying S.
AU - Cheng, Chia Hsiung
AU - Wu, Yu Ting
AU - Wu, Changwei W.
AU - Hsu, Ai Ling
AU - Liu, Chia Yih
AU - Liu, Ho Ling
AU - Davenport, Paul W.
N1 - Funding Information:
The authors wish to thank Chia-Wei Li and the National Taiwan University Imaging Center for Integrated Body, Mind, and Culture Research Center for valuable assistance and equipment support. The authors would also like to extend the gratitude to Dr. Susie Huang for the additional proof reading on the manuscript. This study was supported by MOST-109-2320-B-182-008-MY3 as well as MOST-105-2420-H-182-002-MY3 from the Ministry of Science & Technology in Taiwan, CMRPD1K0081 and BMRPB96 from the Chang Gung Memorial Hospital in Taiwan.
Publisher Copyright:
© 2022
PY - 2022/3
Y1 - 2022/3
N2 - The involvement of neural substrates in respiratory sensory gating remained unclear. This study aimed to investigate cortical and subcortical activations associated with respiratory sensory gating by using functional magnetic resonance imaging. First, we hypothesized that paired occlusions would induce neural activation in cortical and subcortical areas, including the thalamus and sensorimotor cortices. Secondly, we hypothesized that, in terms of parameter estimates in the general linear model, the activation effect size β ratios (βpaired/βsingle) would be less than 2 due to central neural gating mechanism. Forty-six healthy participants were included in the study. Our analyses showed that the βpaired/βsingle ratios for the supramarginal gyrus, basal ganglia, thalamus, and middle frontal gyrus were less than 2. In conclusion, our results demonstrated a non-linear relationship regarding brain neural activations in response to paired versus single occlusions, suggesting that respiratory sensory information is gated at the subcortical and cortical levels.
AB - The involvement of neural substrates in respiratory sensory gating remained unclear. This study aimed to investigate cortical and subcortical activations associated with respiratory sensory gating by using functional magnetic resonance imaging. First, we hypothesized that paired occlusions would induce neural activation in cortical and subcortical areas, including the thalamus and sensorimotor cortices. Secondly, we hypothesized that, in terms of parameter estimates in the general linear model, the activation effect size β ratios (βpaired/βsingle) would be less than 2 due to central neural gating mechanism. Forty-six healthy participants were included in the study. Our analyses showed that the βpaired/βsingle ratios for the supramarginal gyrus, basal ganglia, thalamus, and middle frontal gyrus were less than 2. In conclusion, our results demonstrated a non-linear relationship regarding brain neural activations in response to paired versus single occlusions, suggesting that respiratory sensory information is gated at the subcortical and cortical levels.
KW - Cortical and subcortical substrates
KW - Human fMRI
KW - Paired inspiratory occlusions
KW - Respiratory sensation
KW - Respiratory sensory gating
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U2 - 10.1016/j.biopsycho.2022.108277
DO - 10.1016/j.biopsycho.2022.108277
M3 - Article
C2 - 35077848
AN - SCOPUS:85123679482
SN - 0301-0511
VL - 169
JO - Biological Psychology
JF - Biological Psychology
M1 - 108277
ER -