Abstract
Brain metastases are the most common intracranial tumors, occurring in more than 15% of cancer patients. The treatment of brain metastases involves a multidisciplinary approach that may consist of surgery, radiation therapy (stereotactic radiosurgery or whole-brain radiation therapy), and/or systemic therapy. Unfortunately, all these treatment strategies, as well as the disease process itself, can be associated with debilitating and life-altering neurocognitive adverse effects. Balancing the benefits and toxicities of brain metastasis treatment is a challenging task that medical, radiation, and surgical oncologists face daily. Strategies have been developed to try mitigating these toxicities, such as stereotactic radiosurgery, hippocampal avoidance whole-brain radiation therapy, and “neuroprotective” drugs. Efforts have also been deployed in developing formal instruments/battery of tests to capture neurocognitive changes consistently in patients with brain metastases.
| Original language | English (US) |
|---|---|
| Title of host publication | Central Nervous System Metastases |
| Subtitle of host publication | Diagnosis and Treatment |
| Publisher | Springer International Publishing |
| Pages | 407-425 |
| Number of pages | 19 |
| ISBN (Electronic) | 9783030429584 |
| ISBN (Print) | 9783030429577 |
| DOIs | |
| State | Published - Jan 1 2020 |
Keywords
- Brain metastasis
- Clinical outcome assessment
- Hippocampal avoidance whole-brain radiation therapy
- Memory
- Neurocognitive function
- Neuropsychological testing
- Radiation
- Stereotactic radiosurgery
- Systemic therapy
ASJC Scopus subject areas
- General Medicine