Abstract
Abstract: Neuroendocrine tumors are a rare subset of tumors that are increasing in incidence over the last 4 decades. These tumors occur along the gastrointestinal tract and bronchopulmonary tree and frequently metastasize. Up to 90% of patients with gastroenteropancreatic neuroendocrine tumors develop liver metastases (NeLM) during their clinical course. The development of NeLM and their appropriate management has a profound impact on patient morbidity and mortality. Workup of NeLM involves biopsy to define tumor grade, cross-sectional imaging to delineate the distribution and number of metastases, and hormonal studies to determine tumor functionality. Depending on these three factors, a combination of cytoreductive surgery, liver-directed therapies, and medical management—with cytostatic and cytotoxic chemotherapies, is utilized. The multidisciplinary management of patients with NeLM should carefully consider all these factors. Graphical Abstract: [Figure not available: see fulltext.]
Original language | English (US) |
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Pages (from-to) | 4073-4080 |
Number of pages | 8 |
Journal | Abdominal Radiology |
Volume | 47 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2022 |
Keywords
- Cytoreduction
- DOTATATE
- Hepatectomy
- Liver
- Metastatic
- Neuroendocrine tumors
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging
- Gastroenterology
- Urology