Neurologic Complications of Cancer Immunotherapy

Aseel N. Alsalem, Leslie A. Scarffe, Hannah R. Briemberg, Ashley E. Aaroe, Rebecca Harrison

Research output: Contribution to journalReview articlepeer-review

Abstract

Immunotherapy has revolutionized cancer treatment over the past decade. As it is increasingly introduced into routine clinical practice, immune-related complications have become more frequent. Accurate diagnosis and treatment are essential, with the goal of reduced patient morbidity. This review aims to discuss the various clinical manifestations, diagnosis, treatments, and prognosis of neurologic complications associated with the use of immune checkpoint inhibitors, adoptive T-cell therapies, and T-cell redirecting therapies. We also outline a suggested clinical approach related to the clinical use of these agents.

Original languageEnglish (US)
Pages (from-to)5876-5897
Number of pages22
JournalCurrent Oncology
Volume30
Issue number6
DOIs
StatePublished - Jun 2023

Keywords

  • CAR-T cells
  • checkpoint inhibition
  • immunotherapy
  • neurologic complications

ASJC Scopus subject areas

  • Oncology

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