TY - JOUR
T1 - Neuropeptide S
T2 - A neuropeptide promoting arousal and anxiolytic-like effects
AU - Xu, Yan Ling
AU - Reinscheid, Rainer K.
AU - Huitron-Resendiz, Salvador
AU - Clark, Stewart D.
AU - Wang, Zhiwei
AU - Lin, Steven H.
AU - Brucher, Fernando A.
AU - Zeng, Joanne
AU - Ly, Nga K.
AU - Henriksen, Steven J.
AU - De Lecea, Luis
AU - Civelli, Olivier
N1 - Funding Information:
This work was supported in part by grants from NIH (R.K.R., O.C.) and the Stanley Medical Research Institute (O.C.). We thank Hans-Peter Nothacker for helpful discussions; Christine Gall for critical review of in situ hybridization results; Gary Lynch for help with locomotor experiments; and Valerie Jackson, Hua Zeng, and Alanna Pei Sun for technical assistance.
PY - 2004/8/19
Y1 - 2004/8/19
N2 - Arousal and anxiety are behavioral responses that involve complex neurocircuitries and multiple neurochemical components. Here, we report that a neuropeptide, neuropeptide S (NPS), potently modulates wakefulness and could also regulate anxiety. NPS acts by activating its cognate receptor (NPSR) and inducing mobilization of intracellular Ca2+. The NPSR mRNA is widely distributed in the brain, including the amygdala and the midline thalamic nuclei. Central administration of NPS increases locomotor activity in mice and decreases paradoxical (REM) sleep and slow wave sleep in rats. NPS was further shown to produce anxiolytic-like effects in mice exposed to four different stressful paradigms. Interestingly, NPS is expressed in a previously undefined cluster of cells located between the locus coeruleus (LC) and Barrington's nucleus. These results indicate that NPS could be a new modulator of arousal and anxiety. They also show that the LC region encompasses distinct nuclei expressing different arousal-promoting neurotransmitters.
AB - Arousal and anxiety are behavioral responses that involve complex neurocircuitries and multiple neurochemical components. Here, we report that a neuropeptide, neuropeptide S (NPS), potently modulates wakefulness and could also regulate anxiety. NPS acts by activating its cognate receptor (NPSR) and inducing mobilization of intracellular Ca2+. The NPSR mRNA is widely distributed in the brain, including the amygdala and the midline thalamic nuclei. Central administration of NPS increases locomotor activity in mice and decreases paradoxical (REM) sleep and slow wave sleep in rats. NPS was further shown to produce anxiolytic-like effects in mice exposed to four different stressful paradigms. Interestingly, NPS is expressed in a previously undefined cluster of cells located between the locus coeruleus (LC) and Barrington's nucleus. These results indicate that NPS could be a new modulator of arousal and anxiety. They also show that the LC region encompasses distinct nuclei expressing different arousal-promoting neurotransmitters.
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U2 - 10.1016/j.neuron.2004.08.005
DO - 10.1016/j.neuron.2004.08.005
M3 - Article
C2 - 15312648
AN - SCOPUS:4143111307
SN - 0896-6273
VL - 43
SP - 487
EP - 497
JO - Neuron
JF - Neuron
IS - 4
ER -