Abstract
NEUROTROPHINS provide signals for the invasive neurite outgrowth, differentiation, and survival of developing neurons. The discovery and characterization of the neurotrophins and their receptors are discussed, as well as the current concepts regarding the possible signaling mechanisms of the 2 neurotrophin receptor affinity classes. The involvement of neurotrophism in regulating the death and survival of neuroectodermal derivatives including melanoma are described. Also presented is a hypothesis that trophic support serves as a general mechanism for tumor cell invasion, survival, and clonal selection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 131-139 |
| Number of pages | 9 |
| Journal | Cancer Bulletin |
| Volume | 47 |
| Issue number | 2 |
| State | Published - 1995 |
ASJC Scopus subject areas
- Cancer Research