New directions in the biology and therapy of chronic myeloid leukemia

Albert B. Deisseroth; Wei Zhang; Ying Cha; Tianying Yuan; Hanchun Chen; Simon Sims; Andrzej Wedrychowski; Pei Qing Gao; Laurel Huston; Marylynne Filaccio; David Claxton; Steven Kornblau; Elizabeth Johnson; O. M. Zack Howard; Borje Andersson; Auro Del Giglio; Laurent Gressot; Hagop Kantarjian; Moshe Talpaz; Issa Khouri; Richard Champlin; Michael Andreeff; Eugenia Gaozza; David Seong; Soon Pal Suh; Debra Ellerson; Guiying Hu; Marian Chou

doi:10.3109/10428199209064884

New directions in the biology and therapy of chronic myeloid leukemia

Albert B. Deisseroth, Wei Zhang, Ying Cha, Tianying Yuan, Hanchun Chen, Simon Sims, Andrzej Wedrychowski, Pei Qing Gao, Laurel Huston, Marylynne Filaccio, David Claxton, Steven Kornblau, Elizabeth Johnson, O. M. Zack Howard, Borje Andersson, Auro Del Giglio, Laurent Gressot, Hagop Kantarjian, Moshe Talpaz, Issa KhouriRichard Champlin, Michael Andreeff, Eugenia Gaozza, David Seong, Soon Pal Suh, Debra Ellerson, Guiying Hu, Marian Chou

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Great excitement surrounded the initial discovery of the Philadelphia chromosome translocation and the molecular rearrangement of the abl protooncogene which is generated by this translocation in chronic myelogenous leukemia (CML). In this review, we will discuss how molecular analysis of the biological abnormalities generated in the CML cells by this molecular rearrangement can be applied to new directions in therapy for this disease.

Original language	English (US)
Pages (from-to)	89-95
Number of pages	7
Journal	Leukemia and Lymphoma
Volume	6
Issue number	2
DOIs	https://doi.org/10.3109/10428199209064884
State	Published - 1992

Keywords

Biology
Therapy of CML

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

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10.3109/10428199209064884

Cite this

Deisseroth, A. B., Zhang, W., Cha, Y., Yuan, T., Chen, H., Sims, S., Wedrychowski, A., Gao, P. Q., Huston, L., Filaccio, M., Claxton, D., Kornblau, S., Johnson, E., Zack Howard, O. M., Andersson, B., Giglio, A. D., Gressot, L., Kantarjian, H., Talpaz, M., ... Chou, M. (1992). New directions in the biology and therapy of chronic myeloid leukemia. Leukemia and Lymphoma, 6(2), 89-95. https://doi.org/10.3109/10428199209064884

Deisseroth, AB, Zhang, W, Cha, Y, Yuan, T, Chen, H, Sims, S, Wedrychowski, A, Gao, PQ, Huston, L, Filaccio, M, Claxton, D, Kornblau, S, Johnson, E, Zack Howard, OM, Andersson, B, Giglio, AD, Gressot, L, Kantarjian, H, Talpaz, M, Khouri, I , Champlin, R , Andreeff, M, Gaozza, E, Seong, D, Suh, SP, Ellerson, D, Hu, G & Chou, M 1992, 'New directions in the biology and therapy of chronic myeloid leukemia', Leukemia and Lymphoma, vol. 6, no. 2, pp. 89-95. https://doi.org/10.3109/10428199209064884

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title = "New directions in the biology and therapy of chronic myeloid leukemia",

abstract = "Great excitement surrounded the initial discovery of the Philadelphia chromosome translocation and the molecular rearrangement of the abl protooncogene which is generated by this translocation in chronic myelogenous leukemia (CML). In this review, we will discuss how molecular analysis of the biological abnormalities generated in the CML cells by this molecular rearrangement can be applied to new directions in therapy for this disease.",

keywords = "Biology, Therapy of CML",

author = "Deisseroth, {Albert B.} and Wei Zhang and Ying Cha and Tianying Yuan and Hanchun Chen and Simon Sims and Andrzej Wedrychowski and Gao, {Pei Qing} and Laurel Huston and Marylynne Filaccio and David Claxton and Steven Kornblau and Elizabeth Johnson and {Zack Howard}, {O. M.} and Borje Andersson and Giglio, {Auro Del} and Laurent Gressot and Hagop Kantarjian and Moshe Talpaz and Issa Khouri and Richard Champlin and Michael Andreeff and Eugenia Gaozza and David Seong and Suh, {Soon Pal} and Debra Ellerson and Guiying Hu and Marian Chou",

note = "Funding Information: Acknowledgements We thank Rosemarie Lauzon for expert editorial assistance. We acknowledge grant support from the National Cancer Institute of the United State of America (PO1 CA49639-01AI), the American Cancer Society (IM-580), the Bush Leukemia Fund, the Gillson-Longenbaugh Foundation, the Kleberg Foundation, and the Anderson Chair for Cancer Treatment and Research.",

year = "1992",

doi = "10.3109/10428199209064884",

language = "English (US)",

volume = "6",

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T1 - New directions in the biology and therapy of chronic myeloid leukemia

AU - Deisseroth, Albert B.

AU - Zhang, Wei

AU - Cha, Ying

AU - Yuan, Tianying

AU - Chen, Hanchun

AU - Sims, Simon

AU - Wedrychowski, Andrzej

AU - Gao, Pei Qing

AU - Huston, Laurel

AU - Filaccio, Marylynne

AU - Claxton, David

AU - Kornblau, Steven

AU - Johnson, Elizabeth

AU - Zack Howard, O. M.

AU - Andersson, Borje

AU - Giglio, Auro Del

AU - Gressot, Laurent

AU - Kantarjian, Hagop

AU - Talpaz, Moshe

AU - Khouri, Issa

AU - Champlin, Richard

AU - Andreeff, Michael

AU - Gaozza, Eugenia

AU - Seong, David

AU - Suh, Soon Pal

AU - Ellerson, Debra

AU - Hu, Guiying

AU - Chou, Marian

N1 - Funding Information: Acknowledgements We thank Rosemarie Lauzon for expert editorial assistance. We acknowledge grant support from the National Cancer Institute of the United State of America (PO1 CA49639-01AI), the American Cancer Society (IM-580), the Bush Leukemia Fund, the Gillson-Longenbaugh Foundation, the Kleberg Foundation, and the Anderson Chair for Cancer Treatment and Research.

PY - 1992

Y1 - 1992

N2 - Great excitement surrounded the initial discovery of the Philadelphia chromosome translocation and the molecular rearrangement of the abl protooncogene which is generated by this translocation in chronic myelogenous leukemia (CML). In this review, we will discuss how molecular analysis of the biological abnormalities generated in the CML cells by this molecular rearrangement can be applied to new directions in therapy for this disease.

AB - Great excitement surrounded the initial discovery of the Philadelphia chromosome translocation and the molecular rearrangement of the abl protooncogene which is generated by this translocation in chronic myelogenous leukemia (CML). In this review, we will discuss how molecular analysis of the biological abnormalities generated in the CML cells by this molecular rearrangement can be applied to new directions in therapy for this disease.

KW - Biology

KW - Therapy of CML

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EP - 95

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

IS - 2

ER -

New directions in the biology and therapy of chronic myeloid leukemia

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Keywords

ASJC Scopus subject areas

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