TY - JOUR
T1 - New drug developments for patients with metastatic soft tissue sarcoma
AU - Hartmann, Jörg Thomas
AU - Patel, Shreyaskumar
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2005/7
Y1 - 2005/7
N2 - For the subgroup of patients with inoperable gastrointestinal stromal tumors, progress has been made by the rapid development and approval of the targeted therapy imatinib mesylate. Small round cell sarcomas (SRCT), such as Ewing/primitive neuroectodermal tumor, desmoplastic SRCT, and rhabdomyosarcoma, are chemotherapy-sensitive and potentially curable malignancies that are treated with multimodality dose-intensive neoadjuvant protocols regardless of size or overt metastatic disease. However, the number of effective cytotoxic agents for the treatment of patients with metastatic so-called adult soft tissue sarcoma is limited, especially when patients have failed anthracycline- and ifosfamide-based chemotherapy.
AB - For the subgroup of patients with inoperable gastrointestinal stromal tumors, progress has been made by the rapid development and approval of the targeted therapy imatinib mesylate. Small round cell sarcomas (SRCT), such as Ewing/primitive neuroectodermal tumor, desmoplastic SRCT, and rhabdomyosarcoma, are chemotherapy-sensitive and potentially curable malignancies that are treated with multimodality dose-intensive neoadjuvant protocols regardless of size or overt metastatic disease. However, the number of effective cytotoxic agents for the treatment of patients with metastatic so-called adult soft tissue sarcoma is limited, especially when patients have failed anthracycline- and ifosfamide-based chemotherapy.
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U2 - 10.1007/s11912-005-0054-5
DO - 10.1007/s11912-005-0054-5
M3 - Review article
C2 - 15946590
AN - SCOPUS:23444454023
SN - 1523-3790
VL - 7
SP - 300
EP - 306
JO - Current oncology reports
JF - Current oncology reports
IS - 4
ER -