TY - JOUR
T1 - New insights into molecular mechanisms of diabetic kidney disease
AU - Badal, Shawn S.
AU - Danesh, Farhad R.
N1 - Funding Information:
Support: The development of this journal supplement was funded by Novo Nordisk. The writing of this manuscript was supported by grants from the NIDDK ( RO1DK091310 and RO1DK078900 ). The authors received no other honoraria or remuneration for this work. Technical editing was provided by Watermeadow Medical, funded by Novo Nordisk. Costs associated with publication were funded by Novo Nordisk.
PY - 2014/2
Y1 - 2014/2
N2 - Diabetic kidney disease remains a major microvascular complication of diabetes and the most common cause of chronic kidney failure requiring dialysis in the United States. Medical advances over the past century have substantially improved the management of diabetes mellitus and thereby have increased patient survival. However, current standards of care reduce but do not eliminate the risk of diabetic kidney disease, and further studies are warranted to define new strategies for reducing the risk of diabetic kidney disease. In this review, we highlight some of the novel and established molecular mechanisms that contribute to the development of the disease and its outcomes. In particular, we discuss recent advances in our understanding of the molecular mechanisms implicated in the pathogenesis and progression of diabetic kidney disease, with special emphasis on the mitochondrial oxidative stress and microRNA targets. Additionally, candidate genes associated with susceptibility to diabetic kidney disease and alterations in various cytokines, chemokines, and growth factors are addressed briefly.
AB - Diabetic kidney disease remains a major microvascular complication of diabetes and the most common cause of chronic kidney failure requiring dialysis in the United States. Medical advances over the past century have substantially improved the management of diabetes mellitus and thereby have increased patient survival. However, current standards of care reduce but do not eliminate the risk of diabetic kidney disease, and further studies are warranted to define new strategies for reducing the risk of diabetic kidney disease. In this review, we highlight some of the novel and established molecular mechanisms that contribute to the development of the disease and its outcomes. In particular, we discuss recent advances in our understanding of the molecular mechanisms implicated in the pathogenesis and progression of diabetic kidney disease, with special emphasis on the mitochondrial oxidative stress and microRNA targets. Additionally, candidate genes associated with susceptibility to diabetic kidney disease and alterations in various cytokines, chemokines, and growth factors are addressed briefly.
KW - diabetes mellitus
KW - diabetic kidney disease
KW - End-stage renal disease (ESRD)
KW - pathogenesis
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U2 - 10.1053/j.ajkd.2013.10.047
DO - 10.1053/j.ajkd.2013.10.047
M3 - Article
C2 - 24461730
AN - SCOPUS:84892915037
SN - 0272-6386
VL - 63
SP - S63-S83
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 2 SUPPL.2
ER -