New Therapeutic Approaches for Advanced Gastrointestinal Stromal Tumors

Neeta Somaiah; Margaret von Mehren

doi:10.1016/j.hoc.2008.12.004

New Therapeutic Approaches for Advanced Gastrointestinal Stromal Tumors

Neeta Somaiah, Margaret von Mehren

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

The management of advanced gastronintestinal stromal tumor is increasingly complex because of imatinib refractory disease. Primary resistance to imatinib is uncommon, and most patients progress after development of additional genetic changes. This article reviews management strategies including surgical approaches, local modalities for progressive liver metastases, as well as novel therapeutic agents.

Original language	English (US)
Pages (from-to)	139-150
Number of pages	12
Journal	Hematology/Oncology Clinics of North America
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.hoc.2008.12.004
State	Published - Feb 2009
Externally published	Yes

Keywords

Gastrointestinal stromal tumor
HSP-90 inhibitors
IGF-1R
Nilotinib
Sorafenib
Tyrosine kinase inhibitors

ASJC Scopus subject areas

Hematology
Oncology

Access to Document

10.1016/j.hoc.2008.12.004

Cite this

@article{4ddce5ebd39a4086adaf699bf58da9ec,

title = "New Therapeutic Approaches for Advanced Gastrointestinal Stromal Tumors",

abstract = "The management of advanced gastronintestinal stromal tumor is increasingly complex because of imatinib refractory disease. Primary resistance to imatinib is uncommon, and most patients progress after development of additional genetic changes. This article reviews management strategies including surgical approaches, local modalities for progressive liver metastases, as well as novel therapeutic agents.",

keywords = "Gastrointestinal stromal tumor, HSP-90 inhibitors, IGF-1R, Nilotinib, Sorafenib, Tyrosine kinase inhibitors",

author = "Neeta Somaiah and {von Mehren}, Margaret",

note = "Funding Information: This manuscript was supported in part by NIH grant (CA106588) (to MvM). ",

year = "2009",

month = feb,

doi = "10.1016/j.hoc.2008.12.004",

language = "English (US)",

volume = "23",

pages = "139--150",

journal = "Hematology/Oncology Clinics of North America",

issn = "0889-8588",

publisher = "W.B. Saunders Ltd",

number = "1",

}

TY - JOUR

T1 - New Therapeutic Approaches for Advanced Gastrointestinal Stromal Tumors

AU - Somaiah, Neeta

AU - von Mehren, Margaret

N1 - Funding Information: This manuscript was supported in part by NIH grant (CA106588) (to MvM).

PY - 2009/2

Y1 - 2009/2

N2 - The management of advanced gastronintestinal stromal tumor is increasingly complex because of imatinib refractory disease. Primary resistance to imatinib is uncommon, and most patients progress after development of additional genetic changes. This article reviews management strategies including surgical approaches, local modalities for progressive liver metastases, as well as novel therapeutic agents.

AB - The management of advanced gastronintestinal stromal tumor is increasingly complex because of imatinib refractory disease. Primary resistance to imatinib is uncommon, and most patients progress after development of additional genetic changes. This article reviews management strategies including surgical approaches, local modalities for progressive liver metastases, as well as novel therapeutic agents.

KW - Gastrointestinal stromal tumor

KW - HSP-90 inhibitors

KW - IGF-1R

KW - Nilotinib

KW - Sorafenib

KW - Tyrosine kinase inhibitors

UR - http://www.scopus.com/inward/record.url?scp=60549102273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=60549102273&partnerID=8YFLogxK

U2 - 10.1016/j.hoc.2008.12.004

DO - 10.1016/j.hoc.2008.12.004

M3 - Review article

C2 - 19248977

AN - SCOPUS:60549102273

SN - 0889-8588

VL - 23

SP - 139

EP - 150

JO - Hematology/Oncology Clinics of North America

JF - Hematology/Oncology Clinics of North America

IS - 1

ER -

New Therapeutic Approaches for Advanced Gastrointestinal Stromal Tumors

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this