TY - JOUR
T1 - New thoughts on the pathobiology of regimen-related mucosal injury.
AU - Anthony, Lowell
AU - Bowen, Joanne
AU - Garden, Adam
AU - Hewson, Ian
AU - Sonis, Stephen
PY - 2006/6
Y1 - 2006/6
N2 - BACKGROUND: Our understanding of the biological basis for mucosal barrier injury (mucositis) induced by cancer therapy with radiation or drugs continues to evolve. A patient's mucosal response to cancer therapy appears to be controlled by both global (i.e. gender, underlying systemic disease, race) and tissue specific (i.e. epithelial type, intrinsic endocrine system, local microbial environment, function) factors. CONCLUSION: Interactions of these elements, coupled with underlying genetic influences, most likely govern the risk, course and severity of regimen-related mucosal injury.
AB - BACKGROUND: Our understanding of the biological basis for mucosal barrier injury (mucositis) induced by cancer therapy with radiation or drugs continues to evolve. A patient's mucosal response to cancer therapy appears to be controlled by both global (i.e. gender, underlying systemic disease, race) and tissue specific (i.e. epithelial type, intrinsic endocrine system, local microbial environment, function) factors. CONCLUSION: Interactions of these elements, coupled with underlying genetic influences, most likely govern the risk, course and severity of regimen-related mucosal injury.
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U2 - 10.1007/s00520-006-0058-1
DO - 10.1007/s00520-006-0058-1
M3 - Review article
C2 - 16583189
AN - SCOPUS:33746089967
SN - 0941-4355
VL - 14
SP - 516
EP - 518
JO - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
IS - 6
ER -