NF-ΚB as a target for cancer therapy

Davide Melisi; Paul J. Chiao

doi:10.1517/14728222.11.2.133

NF-ΚB as a target for cancer therapy

Davide Melisi, Paul J. Chiao

Molecular & Cellular Oncology

Research output: Contribution to journal › Review article › peer-review

93 Scopus citations

Abstract

NF-κB transcription factors and the signaling pathways that activate them play a critical role in cancer development, progression and therapy, and recently have become a focal point for intense drug discovery and development efforts. This article presents a critical review on the, different types of inhibitors targeting the NF-κB pathway at several stages.

Original language	English (US)
Pages (from-to)	133-144
Number of pages	12
Journal	Expert Opinion on Therapeutic Targets
Volume	11
Issue number	2
DOIs	https://doi.org/10.1517/14728222.11.2.133
State	Published - Feb 2007

Keywords

Apoptosis
Drug resistance
IΚB kinase
NF-ΚB
NSAID
Proteasome
Target therapy

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1517/14728222.11.2.133

Cite this

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title = "NF-ΚB as a target for cancer therapy",

abstract = "NF-κB transcription factors and the signaling pathways that activate them play a critical role in cancer development, progression and therapy, and recently have become a focal point for intense drug discovery and development efforts. This article presents a critical review on the, different types of inhibitors targeting the NF-κB pathway at several stages.",

keywords = "Apoptosis, Drug resistance, IΚB kinase, NF-ΚB, NSAID, Proteasome, Target therapy",

author = "Davide Melisi and Chiao, {Paul J.}",

year = "2007",

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AU - Chiao, Paul J.

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AB - NF-κB transcription factors and the signaling pathways that activate them play a critical role in cancer development, progression and therapy, and recently have become a focal point for intense drug discovery and development efforts. This article presents a critical review on the, different types of inhibitors targeting the NF-κB pathway at several stages.

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KW - NSAID

KW - Proteasome

KW - Target therapy

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NF-ΚB as a target for cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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